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Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats


, : Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats. Antimicrobial Agents & Chemotherapy 40(6): 1352-1359

Cats were experimentally inoculated parenterally with the ME49 strain of Toxoplasma gondii to characterize the efficacies of two different dosages of orally administered clindamycin hydrochloride in the treatment of ocular toxoplasmosis. Concentrations of clindamycin hydrochloride at levels previously suggested to be inhibitory to T. gondii replication in vitro were achieved in the serum and aqueous humor but not in the cerebrospinal fluid. Antibiotic therapy, initiated 7 days after inoculation, resulted in no significant difference in the morphometric severity of ocular posterior segment lesions compared with that in the control groups. Treatment appeared to blunt T. gondii-specific immunoglobulin M production but had no significant effect on immunoglobulin G titers. Paradoxically, clindamycin administration was associated with increased morbidity and mortality from hepatitis and interstitial pneumonia, which are characteristic of generalized toxoplasmosis. Serum tumor necrosis factor alpha activity was detected at moderate levels in all groups of cats and correlated with the severity of clinical disease. The results of the study suggest that clindamycin, when administered at this specific time interval following inoculation, does not ameliorate ocular lesions and has a detrimental effect on the clinical course of acute, experimental toxoplasmosis in cats. The factors responsible for and the relevance of this detrimental effect to naturally occurring toxoplasmosis in humans and pet cats were not clear from the study but may relate to an antibiotic-associated decrease in the antitoxoplasmic activity of phagocytic cells responsible for the control of T. gondii.

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Accession: 002914950

PMID: 8726000

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Perskvist, N.; Norman, I.; Eklund, C.; Litton, J-Eric.; Dillner, J., 2015: The Swedish cervical cytology biobank: sample handling and storage process. The Swedish Cervical Cytology Biobank (SCCB) is the first national initiative of a prospective repository for liquid-based gynecological cell samples (LBC) from women participating in organized cervical cancer screening programs. Development and i...

Lipkowitz, K.B.; McCracken, R.O., 1993: Molecular modeling: a tool for predicting anthelmintic activity in vivo. The structural and electronic features of the broad-spectrum benzimidazole anthelmintic mebendazole (MBZ, methyl 5-(benzoyl)-benzimidazole-2-carbamate) have been determined using a combination of quantum mechanics, molecular graphics, and molecula...

Poradovský, K.; Spisáková, J.; Dobayová, I.; Mészárosová, A., 1969: Prolonged pregnancy and the danger to the fetus. Ceskoslovenska Gynekologie 34(1): 82-84

Keshava Prasad, T.S.; Goel, R.; Kandasamy, K.; Keerthikumar, S.; Kumar, S.; Mathivanan, S.; Telikicherla, D.; Raju, R.; Shafreen, B.; Venugopal, A.; Balakrishnan, L.; Marimuthu, A.; Banerjee, S.; Somanathan, D.S.; Sebastian, A.; Rani, S.; Ray, S.; Harrys Kishore, C.J.; Kanth, S.; Ahmed, M.; Kashyap, M.K.; Mohmood, R.; Ramachandra, Y.L.; Krishna, V.; Rahiman, B.Abdul.; Mohan, S.; Ranganathan, P.; Ramabadran, S.; Chaerkady, R.; Pandey, A., 2009: Human Protein Reference Database--2009 update. Human Protein Reference Database (HPRD--http://www.hprd.org/), initially described in 2003, is a database of curated proteomic information pertaining to human proteins. We have recently added a number of new features in HPRD. These include Phospho...

Cowen, J.B.; Sjostrom, B.F.; Doughty, A.S.; Schiffer, R.B., 2007: Case-finding for MS prevalence studies in small communities requires a community-based approach. In response to citizen concerns in 5 small Illinois towns, community-based case-finding determined the prevalence of multiple sclerosis ( MS). Potential cases were identified through town meetings, publicity, advocacy groups and local volunteer o...

Neuhofer, W.; Mueller, E.; Burger Kentischer, A.; Fraek, M.L.isa; Thurau, K.; Beck, F.X., 1998: Pretreatment with hypertonic NaCl protects MDCK cells against high urea concentrations. In antidiuresis, the cells of the renal medulla are exposed to high extracellular concentrations of NaCl and urea. Since urea equilibrates with the intracellular compartment and is known to perturb intracellular macromolecules, high urea concentra...

Anonymous, 1956: Lithium compounds. Mineral Information Service 9(9): 1-8

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Rudolf, E.; Dournon, C., 1996: Activity of peptidase-1, a sex linked enzyme, during larval development at normal or sex reversal rearing temperature and according to tissues in adults of Pleurodeles waltl (urodele amphibian). Peptidase-1 is a sex linked marker routinely used in laboratories to determine the sexual genotype of Pleurodeles waltl individuals. This urodele amphibia displays a ZZ/ZW sex determination system at room temperature but can be sex-reversed by hea...