+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats

, : Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats. Antimicrobial Agents & Chemotherapy 40(6): 1352-1359

Cats were experimentally inoculated parenterally with the ME49 strain of Toxoplasma gondii to characterize the efficacies of two different dosages of orally administered clindamycin hydrochloride in the treatment of ocular toxoplasmosis. Concentrations of clindamycin hydrochloride at levels previously suggested to be inhibitory to T. gondii replication in vitro were achieved in the serum and aqueous humor but not in the cerebrospinal fluid. Antibiotic therapy, initiated 7 days after inoculation, resulted in no significant difference in the morphometric severity of ocular posterior segment lesions compared with that in the control groups. Treatment appeared to blunt T. gondii-specific immunoglobulin M production but had no significant effect on immunoglobulin G titers. Paradoxically, clindamycin administration was associated with increased morbidity and mortality from hepatitis and interstitial pneumonia, which are characteristic of generalized toxoplasmosis. Serum tumor necrosis factor alpha activity was detected at moderate levels in all groups of cats and correlated with the severity of clinical disease. The results of the study suggest that clindamycin, when administered at this specific time interval following inoculation, does not ameliorate ocular lesions and has a detrimental effect on the clinical course of acute, experimental toxoplasmosis in cats. The factors responsible for and the relevance of this detrimental effect to naturally occurring toxoplasmosis in humans and pet cats were not clear from the study but may relate to an antibiotic-associated decrease in the antitoxoplasmic activity of phagocytic cells responsible for the control of T. gondii.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 002914950

PMID: 8726000

PDF Full Text: Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Kim, B.Kyung.; Ahn, S.Hoon.; Seong, J.Sil.; Park, J.Yong.; Kim, D.Young.; Kim, J.Kyung.; Lee, D.Youn.; Lee, K.Hoon.; Han, K-Hyub., 2011: Early α-fetoprotein response as a predictor for clinical outcome after localized concurrent chemoradiotherapy for advanced hepatocellular carcinoma. Liver International 31(3): 369-376

Behnke, J.M.; Wakelin, D., 1973: The survival of Trichuris muris in wild populations of its natural hosts. The results of experimental infections of Trichuris muris in wild field mice (Apodemus sylvaticus) and laboratory-bred wild house mice (Mus musculus) showed that the parasite elicited an immune response similar to that previously described in stra...

RUSSELL.K.P.; ROSE.H.; STARR.P., 1956: Radioactive iodine during pregnancy; effects on maternal and fetal functions. Transactions of the Pacific Coast Obstetrical and Gynecological Society 24: 62-70; Discussion 70-3

van de Vusse, A.C.; Goossens, V.J.; Kemler, M.A.; Weber, W.E., 2001: Screening of patients with complex regional pain syndrome for antecedent infections. This study was designed to investigate whether Complex Regional Pain Syndrome type I (CRPS I) could be linked to any previous infection. Fifty-two patients with CRPS I of one extremity were screened for the presence of antibodies against mostly ne...

Hu, S-Zhen.; Chen, C-Feng., 2011: Hg2+ recognition by triptycene-derived heteracalixarenes: selectivity tuned by bridging heteroatoms and macrocyclic cavity. The binding properties of triptycene-derived oxacalixarenes containing 1,8-naphthyridine subunits 1a and 1b toward metal ions were investigated in detail by spectroscopic methods. A couple of new N,O-bridged diazadioxacalixarenes 2a, 2b were synth...

Marti, O.; Harbuz, M.S.; Andres, R.; Lightman, S.L.; Armario, A., 1999: Activation of the hypothalamic-pituitary axis in adrenalectomised rats: Potentiation by chronic stress. The influence of chronic stress on the status of the hypothalamo-pituitary-adrenal (HPA) axis of sham-operated and adrenalectomised rats was assessed. Animals underwent bilateral adrenalectomy (ADX) and 3 days later they were either left undisturb...

Nur A., 1987: Seismic rock properties for reservoir descriptions and monitoring. Pages 203-237 1987

Becker, Kurt, 1949: Untersuchungen uber das Farbmuster und das Wachstum der Molluskenschale. Variability of the longitudinal and the cross component in the colored designs of Theodoxus fluviatilis and Dreissensia polymorpha are descr. Design peculiarities of saltwater Theodoxus were maintained more than a generation when bred in fresh wat...

BARBER.H.N.; PATON.D.M., 1952: A gene controlled flowering inhibitor in Pisum. Nature 169(4301): 592-592

Haridas, C.V.; Rajarshi, M.B., 2001: A stochastic model for evolution of sociality in insects. We study population biology of eusocial insects such as Ropalidia marginata through a stochastic model based on random (matrix) difference equations. This facilitates a study of dynamics of such populations when the survival and other rates vary r...