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Prolonged clearance of microfilaraemia in patients with bancroftian filariasis after multiple high doses of ivermectin or diethylcarbamazine



Prolonged clearance of microfilaraemia in patients with bancroftian filariasis after multiple high doses of ivermectin or diethylcarbamazine



Transactions of the Royal Society of Tropical Medicine and Hygiene 90(6): 684-688



In a double-blind trial in Sri Lanka on 37 asymptomatic microfilaraemic subjects (minimum 400 mff/ml) with Wuchereria bancrofti infection, the safety, tolerability and macrofilaricidal efficacy of 12 fortnightly doses of ivermectin, 400 micro g/kg, was compared with 12 fortnightly doses of diethylcarbamazine, 10 mg/kg (DEC group), over a period of 129 weeks after treatment. A control group (LDIC group) was treated with low dose ivermectin to clear microfilaraemia, for ethical reasons.

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Accession: 002932716

Download citation: RISBibTeXText

PMID: 9015519

DOI: 10.1016/s0035-9203(96)90437-x


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