Signal transduction in Pneumocystis carinii: characterization of the genes (pcg1) encoding the alpha subunit of the G protein (PCG1) of Pneumocystis carinii carinii and Pneumocystis carinii ratti
Smulian, A.G.; Ryan, M.; Staben, C.; Cushion, M.
Infection and Immunity 64(3): 691-701
ISSN/ISBN: 0019-9567 PMID: 8641768 Accession: 002957101
Signal transduction pathways in P. carinii were characterized by cloning a G-protein alpha subunit (G- alpha ) of P. carinii carinii and P. carinii ratti by PCR amplification and hybridization screening. The gene encoding the G- alpha was present in single copy on a 450-kb chromosome of P. carinii carinii and on a 420-kb chromosome of P. carinii ratti. The 1062-bp G- alpha open reading fame is interrupted by 9 introns.