+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Survival in a case of massive paraquat ingestion



Survival in a case of massive paraquat ingestion



Chest 107(1): 285-289



Serious exposure to the herbicide paraquat usually results in death, either due to gastrointestinal caustic lesions, shock, and acute respiratory distress syndrome or related to the progressive development of pulmonary fibrosis associated with refractory hypoxemia. We report a case of suicidal paraquat ingestion in a 59-year-old man. Most of the indicators of poor prognosis were encountered in this patient. Treatment consisted of early digestive decontamination and hemodialysis, followed by antioxidant therapy, including the administration of deferoxamine (100 mg/kg in 24 h) and a continuous infusion of acetylcysteine (300 mg/kg/d during 3 weeks). The patient only developed a nonoliguric acute renal failure, a mild alteration of liver tests, and an impairment of CO transfer factor without any respiratory complaint. Renal and hepatic disturbances completely resolved within 1 month, whereas CO transfer factor remained altered 14 months later. This observation suggests that early administration of an antioxidant therapy, including deferoxamine and acetylcysteine could be usefully associated with measures that prevent digestive absorption or enhance elimination to limit systemic toxicity in potentially fatal paraquat poisoning.

(PDF emailed within 0-6 h: $19.90)

Accession: 002973064

Download citation: RISBibTeXText

PMID: 7813297

DOI: 10.1378/chest.107.1.285


Related references

Survival after massive intentional overdose of paraquat. South African Medical Journal 98(5): 370-372, 2008

Improvement in survival after paraquat ingestion following introduction of a new formulation in Sri Lanka. Plos Medicine 5(2): E49-E49, 2008

Survival, growth, and histopathological effects of paraquat ingestion in nestling American kestrels (Falco sparverius). Archives of Environmental Contamination and Toxicology 14(4): 495-500, 1985

Massive ibuprofen ingestion with survival. Journal of Toxicology Clinical Toxicology 38(1): 55-57, 2000

Survival after massive procainamide ingestion. American Journal of Cardiology 32(5): 727-730, 1973

Massive phenobarbital ingestion with survival. JAMA 202(12): 1106-1107, 1967

Survival following massive arsenic ingestion. American Journal of Emergency Medicine 6(6): 602-606, 1988

Survival following massive barbiturate ingestion. JAMA 198(3): 322-323, 1966

Survival after massive arsenic trioxide ingestion. Veterinary & Human Toxicology 29(6): 481, 1987

Survival after a massive hydrofluoric acid ingestion. Journal of Toxicology Clinical Toxicology 35(3): 307-309, 1997

Survival after a massive hydrofluoric acid ingestion with ECG changes. American Journal of Emergency Medicine 19(5): 458-460, 2001

Survival after massive "ecstasy" (MDMA) ingestion. Intensive Care Medicine 25(6): 640-641, 1999

A case of fatal interstitial pneumonitis after paraquat ingestion. Nihon Kyobu Shikkan Gakkai Zasshi 16(12): 919-925, 1978

Survival of acute hypernatremia due to massive soy sauce ingestion. Journal of Emergency Medicine 45(2): 228-231, 2014