+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Susceptibility of Candida albicans pretreated with ketoconazole and 5-fluorocytosine to fungicidal activity of leukocytes and serum

Susceptibility of Candida albicans pretreated with ketoconazole and 5-fluorocytosine to fungicidal activity of leukocytes and serum

Journal of ChemoTherapy 7 Suppl 4: 21-22

The fungicidal activity of human polymorphonuclear leukocytes (PMNs) against C. albicans ATCC 10231 pretreated for 6 h with 1 mg/litre of ketoconazole and 4 mg/litre of 5-fluorocytosine was investigated. The max. decrease in fungal growth was found in pretreated yeast cultures exposed to PMNs and serum (TP). For both drugs the decreases in TP cultures compared with untreated yeasts exposed to both serum and PMNs (CP) were significant (P<0.05) at 1, 2 and 3 h after drug removal.

(PDF emailed within 1 workday: $29.90)

Accession: 002973246

Download citation: RISBibTeXText

PMID: 8904093

Related references

In vitro susceptibility of Candida albicans, isolated from oral swabs and stool samples to clotrimazole, ketoconazole, miconazole, econazole and 5-fluorocytosine. Infeksiyon Dergisi = Turkish Journal of Infection 12(4): 521-524, 1998

Studies on antifungal activity of ketoconazole (KW-1414). IV. Effect of ketoconazole on mycelial outgrowth and elongation of Candida albicans and intracellular killing by polymorphonuclear leukocytes. Japanese Journal of Medical Mycology 24(3): 234-240, 1983

The activity of ketoconazole in mixed cultures of leukocytes and Candida albicans. Sabouraudia 18(3): 197-210, 1980

Sensitivity testing with ketoconazole in an assay containing Candida albicans, human polymorphonuclear leukocytes and serum. European Journal of Clinical Microbiology 5(6): 665-668, 1986

Fungicidal activity and chemotactic response of polymorphonuclear leukocytes to Candida albicans in lymphoma and leukemia. Ibid: Pan American Health Organization: Proceedings of the Fourth International Conference on the Mycoses The black and white yeasts Brasilia, DF, Brazil, 6-8 June, 1977: 277-281, 1978

Effect of ketoconazole on the fungicidal action of amphotericin B in Candida albicans. Antimicrobial Agents and ChemoTherapy 23(1): 185-187, 1983

Fungicidal activity of candida albicans induced murine lymphokine activated killer cells against candida albicans hyphae in vitro. Journal of General Microbiology 137(12): 2851-2856, 1991

The susceptibility of Candida albicans to amphotericin B, nystatin, and 5-fluorocytosine. Medical Journal of Australia 2(22): 749-750, 1977

Fungicidal and phagocytic activity against "Candida albicans" of human neutrophils in serum depleted in C3 and C4. Annales de Microbiologie 126(1): 75-81, 1975

Fungicidal activity and morphological alterations of Candida albicans induced by echinocandins: study of strains with reduced caspofungin susceptibility. Mycoses 54(4): E62-E68, 2011

Effects of media formulation on candida albicans susceptibility to 5 fluorocytosine. Abstracts of the Annual Meeting of the American Society for Microbiology 85: 369, 1985

The Activity of Ketoconazole on Clinical Isolates of Candida Albicans Cultured in a Mycelium Promoting Medium Die Wirkung von Ketoconazol auf Candida albicans aus klinischem Material unter Verwendung eines Mediums, das die Myzelbildung stimuliert. Mycoses 24(10): 596-602, 1981

A study of 666 strains of Candida albicans: correlation between serotype and susceptibility to 5-fluorocytosine. Journal of Infectious Diseases 139(5): 590-594, 1979

Phagocytic and fungicidal activity with respect to Candida albicans of human neutrophilic polymorphs in the presence of serum without C3 and C4. Annales de Microbiologie, A 126(1): 75-81, 1975

Susceptibility to 5-fluorocytosine and prevalence of serotype in 402 Candida albicans isolates from the United States. Antimicrobial Agents and ChemoTherapy 22(3): 482-487, 1982