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Susceptibility of Candida albicans pretreated with ketoconazole and 5-fluorocytosine to fungicidal activity of leukocytes and serum



Susceptibility of Candida albicans pretreated with ketoconazole and 5-fluorocytosine to fungicidal activity of leukocytes and serum



Journal of ChemoTherapy 7 Suppl 4: 21-22



The fungicidal activity of human polymorphonuclear leukocytes (PMNs) against C. albicans ATCC 10231 pretreated for 6 h with 1 mg/litre of ketoconazole and 4 mg/litre of 5-fluorocytosine was investigated. The max. decrease in fungal growth was found in pretreated yeast cultures exposed to PMNs and serum (TP). For both drugs the decreases in TP cultures compared with untreated yeasts exposed to both serum and PMNs (CP) were significant (P<0.05) at 1, 2 and 3 h after drug removal.

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Accession: 002973246

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PMID: 8904093


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