+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Susceptibility of Helicobacter pylori and Candida spp. to the east African plant Terminalia spinosa



Susceptibility of Helicobacter pylori and Candida spp. to the east African plant Terminalia spinosa



Arzneimittel-Forschung 46(5): 539-540



Trees of the genus Terminalia have long been used in the traditional medicine of Kenya (East Africa). In an ethnopharmacological approach, extracts of the stem bark of Terminalia spinosa were investigated for antibacterial and antifungal activity. The extracts were active against Helicobacter pylori, with the following minimum inhibitory concentrations (MIC): MIC-50 of 125 mg/l, MIC-90 of 250 mg/l, and MIC-range of 62.5-500 mg/l. Yeasts of the genus Candida showed a similar susceptibility. The results indicate that the plant is a source of antimicrobial compounds with therapeutic potential.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 002973259

Download citation: RISBibTeXText

PMID: 8737643


Related references

Terminalia catappa L.: a medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models. Journal of Ethnopharmacology 159: 285-295, 2015

Activity of east African medicinal plants against Helicobacter pylori. ChemoTherapy 42(5): 315-317, 1996

Genomes of two chronological isolates (Helicobacter pylori 2017 and 2018) of the West African Helicobacter pylori strain 908 obtained from a single patient. Journal of Bacteriology 193(13): 3385-3386, 2011

Marked susceptibility of South African Helicobacter pylori strains to ciprofloxacin and amoxicillin: clinical implications. South African Medical Journal 100(1): 49-52, 2010

Interim recommendations for the presowing treatment of Terminalia brownii and Terminalia spinosa. Technical Note Kenya Forestry Research Institute; ( 9): i + 17 pp., 1990

Antibacterial and cytotoxic activities of Terminalia stenostachya and Terminalia spinosa. Tanzania Journal of Health Research 13(2): 119-124, 2011

Effect on cell surface hydrophobicity and susceptibility of Helicobacter pylori to medicinal plant extracts. FEMS microbiology letters 172(1): 41-45, 1999

Results of a multicentre European survey in 1991 of metronidazole resistance in Helicobacter pylori. European Study Group on Antibiotic Susceptibility of Helicobacter pylori. European Journal of Clinical Microbiology & Infectious Diseases 11(9): 777-781, 1992

Anti-Helicobacter pylori activity of Terminalia macroptera root. Fitoterapia 83(5): 872-876, 2012

African, Asian or Indian enigma, the East Asian Helicobacter pylori: facts or medical myths. Journal of Digestive Diseases 10(2): 77-84, 2009

Antibacterial activity of black myrobalan (Terminalia chebula Retz) against Helicobacter pylori. International Journal of Antimicrobial Agents 18(1): 85-88, 2001

A rare co-existence of Helicobacter pylori, Candida albicans and Candida keyfr in a giant gastric ulcer. Turkish Journal of Gastroenterology 25(4): 435-436, 2014