+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin



Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin



Lancet 349(9047): 236-240



Low serum concentrations of mannose-binding lectin (MBL) are associated with increased susceptibility to recurrent infection. Three variant alleles in the MBL gene (B, C, and D), cause low serum concentrations of the protein. We investigated whether variant alleles of MBL affect susceptibility to infection with HIV and progression of AIDS. Between 1983 and 1986, all men who attended two clinics in Copenhagen for HIV screening were invited to take part in our study. We investigated the prevalence of variant alleles of MBL (detected by PCR) and assessed the prognostic value of these alleles and the corresponding serum MBL concentrations (measured by ELISA) in 96 homosexual men with HIV infection and in two control groups (123 healthy adults and 36 HIV-negative homosexual men at high risk of HIV infection because of their sexual behaviour). Follow-up was for up to 10 years. Eight (8%) of the HIV-infected men were homozygous for the variant MBL alleles compared with one (0.8%) of the healthy controls (p = 0.005) and none of the high-risk homosexual controls (p = 0.05). We found no significant association between MBL genotype and time from first positive HIV test to progression of AIDS (p = 0.8). However, in the 61 HIV-infected men who developed AIDS, the median survival time was significantly shorter after the AIDS diagnosis for men who were carriers of the variant alleles (both homozygous and heterozygous) than for men homozygous for the normal MBL allele (11 [IQR 4-21] vs 18 months [9-44], p = 0.007). Among men who developed AIDS, there was a significant difference in survival time between those with serum MBL concentrations below the lower quartile, those within the IQR, and those above the upper quartile (p = 0.02). Multivariate analysis showed that men who developed AIDS and had low serum MBL concentrations had an increased rate of rapid death, independently of CD4 T-cell counts at AIDS diagnosis. Our findings suggest that homozygous carriers of variant MBL alleles are at increased risk of HIV infection, either directly or indirectly because of increased susceptibility to coinfections. These alleles are also associated with a significantly shorter survival time after a diagnosis of AIDS.

(PDF emailed within 0-6 h: $19.90)

Accession: 002973437

Download citation: RISBibTeXText

PMID: 9014910

DOI: 10.1016/s0140-6736(96)08440-1


Related references

Mannose-binding lectin: variant alleles correlate with AIDS progression. Immunology Today 18(4): 148-0, 1997

Presence of the variant mannose-binding lectin alleles associated with slower progression to AIDS. AIDS 12(17): 2275-2280, Dec 3, 1998

Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. Journal of Infectious Diseases 185(10): 1517-1520, 2002

Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections. Genes & Immunity 4(5): 362-367, 2003

Infection-susceptibility alleles of mannose-binding lectin are associated with increased carotid plaque area. Journal of Investigative Medicine 48(3): 198-202, 2000

Mannose-binding lectin in susceptibility and progression of HIV-1 infection in children. Antiviral Therapy 11(4): 499-505, 2006

No Association between Mannose-Binding Lectin Alleles and Susceptibility to Chronic Hepatitis B Virus Infection in German Patients. Experimental and Clinical Immunogenetics 15(3): 130-133, 1998

No association between mannose-binding lectin alleles and susceptibility to chronic hepatitis B virus infection in German patients. Experimental and Clinical Immunogenetics 15(3): 130-133, 1998

Mannose-binding lectin variant alleles and HLA-DR4 alleles are associated with giant cell arteritis. Journal of Rheumatology 29(10): 2148-2153, 2002

Variant mannose-binding lectin alleles are associated with celiac disease. Immunogenetics 54(8): 596-598, 2002

Mannose-binding lectin in HIV infection: relation to disease progression and highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes 32(4): 354-361, 2003

The role of variant alleles of the mannose-binding lectin in the inhibitor development in severe hemophilia A. Thrombosis Research 179: 140-146, 2019

Mannose-binding lectin (MBL) deficiency. Variant alleles in a midwestern population of the United States. Annals of Allergy, Asthma and Immunology 82(2): 134-8, 141; Quiz 142-3, 1999

Lack of association of mannose binding lectin variant alleles with systemic lupus erythematosus. Annals of the Rheumatic Diseases 65(2): 278-279, 2006

Association of variant alleles of mannose-binding lectin with severity of liver disease in cystic fibrosis. American Journal of Human Genetics 67(4 Supplement 2): 26, 2000