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The catalytic domain of acanthamoeba myosin I heavy chain kinase. II. Expression of active catalytic domain and sequence homology to p21-activated kinase (PAK)



The catalytic domain of acanthamoeba myosin I heavy chain kinase. II. Expression of active catalytic domain and sequence homology to p21-activated kinase (PAK)



Journal of Biological Chemistry 271(43): 27056-27062



Acanthamoeba castellanii myosin I heavy chain (MIHC) kinase is a monomeric 97-kDa protein that is activated by binding to acidic phospholipids or by autophosphorylation. Activation by phospholipids is inhibited by Ca2+-calmodulin. The cloning, sequencing and expression of the cDNA corresponding to the COOH-terminal 35 kDa catalytic domain of MIHC kinase are described.

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Accession: 002980030

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PMID: 8900196


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