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The cellular prion protein binds copper in vitro

, : The cellular prion protein binds copper in vitro. Nature London 390(6661): 684-687

The amino terminus of the normal cellular form of prion protein (PrPC) contains the octapeptide PHGGGWGQ which is repeated 4 times and is among the the best preserved regions of mammalian PrPC. It was shown that the amino-terminal domain of PrPC exhibits 5 to 6 sites that bind copper presented as a glycine chelate. At neutral pH, binding occurs with positive cooperativity, with binding affinity compatible with estimates for extracellular, labile copper.

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