EurekaMag.com logo
+ Translate

The chromosomal distribution of mouse odorant receptor genes


, : The chromosomal distribution of mouse odorant receptor genes. Proceedings of the National Academy of Sciences of the United States of America 93(2): 884-888

Odorant receptors (ORs) on nasal olfactory sensory neurons are encoded by a large multigene family. Each member of the family is expressed in a small percentage of neurons that are confined to one of several spatial zones in the nose but are randomly distributed throughout that zone. This pattern of expression suggests that when the sensory neuron selects which OR gene to express it may be confined to a particular zonal gene set of several hundred OR genes but select from among the members of that set via a stochastic mechanism. Both locus-dependent and locus-independent models of OR gene choice have been proposed. To investigate the feasibility of these models, we determined the chromosomal locations of 21 OR genes expressed in four different spatial zones. We found that OR genes are clustered within multiple loci that are broadly distributed in the genome. These loci lie within paralogous chromosomal regions that appear to have arisen by duplications of large chromosomal domains followed by extensive gene duplication and divergence. Our studies show that OR genes expressed in the same zone map to numerous loci; moreover, a single locus can contain genes expressed in different zones. These findings raise the possibility that OR gene choice may be locus-independent or involve consecutive stochastic choices.

Accession: 002980315

PMID: 8570653

DOI: 10.2307/38566

Download PDF Full Text: The chromosomal distribution of mouse odorant receptor genes


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Ferreira, T.; Wilson, S.R.; Choi, Y.Gi.; Risso, D.; Dudoit, S.; Speed, T.P.; Ngai, J., 2014: Silencing of odorant receptor genes by G protein βγ signaling ensures the expression of one odorant receptor per olfactory sensory neuron. Olfactory sensory neurons express just one out of a possible ∼ 1,000 odorant receptor genes, reflecting an exquisite mode of gene regulation. In one model, once an odorant receptor is chosen for expression, other receptor genes are suppressed by...

Zhang, X.; Rodriguez, I.; Mombaerts, P.; Firestein, S., 2004: Odorant and vomeronasal receptor genes in two mouse genome assemblies. Odorant receptors (ORs) and vomeronasal receptors (V1Rs and V2Rs) are large superfamilies of chemosensory receptors. As an extension of previous research using the 2001 Celera mouse genome assembly, we analyzed OR and V1R genes in the 2002 public...

Xie, S.Y.; Feinstein, P.; Mombaerts, P., 2000: Characterization of a cluster comprising ~100 odorant receptor genes in mouse. With ~1000 genes, the odorant receptor (OR) gene repertoire is the largest gene family in the mouse genome. Here we have established a 129/Sv BAC contig for mouse OR gene cluster 7 (Olfr7) on Chromosome (Chr) 9. The assembled ~2-Mb contig consists...

Tazir, B.; Khan, M.; Mombaerts, P.; Grosmaitre, X., 2015: The extremely broad odorant response profile of mouse olfactory sensory neurons expressing the odorant receptor MOR256-17 includes trace amine-associated receptor ligands. The mouse olfactory system employs ~1100 G-protein-coupled odorant receptors (ORs). Each mature olfactory sensory neuron (OSN) is thought to express just one OR gene, and the expressed OR determines the odorant response properties of the OSN. The...

Xie, S.Y.; Feinstein, P.; Mombaerts, P., 2000: Characterization of a cluster comprising approximately 100 odorant receptor genes in mouse. With -1000 genes, the odorant receptor (OR) gene repertoire is the largest gene family in the mouse genome. Here we have established a 129/Sv BAC contig for mouse OR gene cluster 7 (Olfr7) on Chromosome (Chr) 9. The assembled approximately 2-Mb co...

Xie, S.Y.; Feinstein, P.; Mombaerts, P., 2000: Characterization of a cluster comprising apprx100 odorant receptor genes in mouse. With apprx1000 genes, the odorant receptor (OR) gene repertoire is the largest gene family in the mouse genome. Here we have established a 129/Sv BAC contig for mouse OR gene cluster 7 (Olfr7) on Chromosome (Chr) 9. The assembled apprx2-Mb contig...

Fuss, S.H.; Omura, M.; Mombaerts, P., 2007: Local and cis effects of the H element on expression of odorant receptor genes in mouse. From the approximately 1,200 odorant receptor (OR) genes in the mouse genome, an olfactory sensory neuron is thought to express only one gene. The mechanisms of OR gene choice are not understood. A 2.1 kilobase region (the H element) adjacent to a...

Bulger, M.; Von Doorninck, J.Hikke; Saitoh, N., 1999: Conservation of sequence and structure flanking the mouse and human b-globin loci: the b-globin genes are embedded within an array of odorant receptor genes. Regions flanking the b-globin locus in both mouse and human were sequenced. The b-globin genes in mouse and human are located in a linear array that is associated with a positive regulatory element that is situated 5' to the genes known as th...

Bozza, T.C.; Feinstein, P.; Zheng, C.; Mombaerts, P., 1999: Odorant responsiveness correlates with odorant receptor expression in mouse olfactory sensory neurons. Society for Neuroscience Abstracts 25(1-2): 1050

Burger, J.L.; Jeerage, K.M.; Bruno, T.J., 2016: Direct nuclear magnetic resonance observation of odorant binding to mouse odorant receptor MOR244-3. Mammals are able to perceive and differentiate a great number of structurally diverse odorants through the odorant's interaction with odorant receptors (ORs), proteins found within the cell membrane of olfactory sensory neurons. The natural g...