EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The effect of short-term diets rich in fish, red meat, or white meat on thromboxane and prostacyclin synthesis in humans






Lipids 32(6): 635-644

The effect of short-term diets rich in fish, red meat, or white meat on thromboxane and prostacyclin synthesis in humans

Foods which increase tissue arachidonic acid levels have been proposed to increase thrombosis tendency, presumably through increased platelet aggregation. This study examined the effect of doubling the dietary arachidonic acid (20:4n-6) using meat- or fish-based diets on the systemic production of prostacyclin (PGI-2) and thromboxane (TXA-2) in 29 healthy, nonsmoking adults. There were three, 3-wk low-fat dietary periods ( lt 15% energy as fat) in which subjects consumed a vegetarian diet for 1 wk followed by 2 wk on diets containing meat or fish as sources of 20:4n-6. Between each diet period, there was a 3-wk washout period, during which subjects returned to their normal diets. The level of 20:4n-6 consumed during the last 2 wk of each study was approximately double the usual intake (mean 140 mg/d), while the mean eicosapentaenoic acid (20:5n-3) content of the diets varied from 1 mg/d on the white meat diet to 70 mg/d on the red meat diet and to 847 mg/d on the fish diet. The serum phospholipid (PL) 20:4n-6/20:5n-3 ratios were 11:1 on the vegetarian diet, 15:1 on the white meat diet, 8:1 on the red meat diet, and 2:1 on the fish diet (P lt 0.001). Neither white nor red meat diets affected platelet 20:4n-6 levels, platelet aggregation, ex vivo platelet TXB-2 production, or the systemic PGI-2 or TXA-2 production as measured by gas chromatography-mass spectrometry analysis of the excretion levels of the principal urinary metabolites 2,3-dinor-6-keto-PGF-1alpha (PGI-2-M) and 11-dehydro-TXB-2 (TXA-2-M), respectively. The fish diet decreased the 20:4n-6/20:5n-3 ratio in platelet PL from the baseline level of 45:1 to 13:1 (P lt 0.001), had no effects on platelet aggregation, but significantly decreased platelet TXB-2 production (collagen-stimulated) and TXA-2-M production, while PGI-2-M levels were unaltered. These results indicate that short-term diets which double the usual 20:4n-6 intake using white meat (175-330 g/d) or red meat (275-530 g/d) are not associated with an increased TXA-2 production, but this does not rule out the adverse effects of 20:4n-6 at higher levels in the diet, or for more prolonged periods. Short-term diets containing fish (100-200 g/d with 90-210 mg/d 20:4n-6 and approximately 650-1000 mg/d 20:5n-3) led to significant increases in platelet 20:5n-3 levels and a decrease in the ex vivo and systemic TXA-2 production.

(PDF same-day service: $19.90)

Accession: 002984021

PMID: 9208393

DOI: 10.1007/s11745-997-0081-5



Related references

Short-term diets rich in arachidonic acid influence plasma phospholipid polyunsaturated fatty acid levels and prostacyclin and thromboxane production in humans. Journal of Nutrition 126(4 Suppl): 1110s-1114s, 1996

Replacing red meat and processed red meat for white meat, fish, legumes or eggs is associated with lower risk of incidence of metabolic syndrome. Clinical Nutrition (): -, 2016

The survival of chick inoculated with Salmonella gallinarium and given diets containing extracted meat or fish meals, and meat or fish protein. Proceedings of the Nutrition Society 31(3): 96A-97A, 1972

A nutritional evaluation of diets containing meat meal for growing pigs. 2. The effect of level of meat meal or meat and bone meal in wheat based diets. Austral. J. Exp. Agric. Animal Husb, 9: 408-412, 1969

Fish meat powder as a substitute for horse meat protein in synthetic diets used for feeding experiments. Sci. Papers Inst. Phys. Chem. Res. Tokyo. 24: 335-340, 1934

Fish-meat powder as the substitute of horse-meat protein in the synthetic diets used for feeding experiments. Sci Papers Inst Phys And Chem Res [Tokyo] 25(523): 335-340, 1934

Effects of hypothyroidism and short-term aging on whole blood thromboxane and arterial prostacyclin synthesis. Journal of Laboratory and Clinical Medicine 110(5): 576-582, 1987

Effects of vitamin E and fish oil inclusion in broiler diets on meat fatty acid composition and on the flavour of a composite sample of breast meat. Journal of the Science of Food and Agriculture 90(10): 1628-1633, 2011

Identification and characterisation of headspace volatiles of fish miso, a Japanese fish meat based fermented paste, with special emphasis on effect of fish species and meat washing. Food Chemistry0: 2, 621-631, 2010

The lipid-lowering effect of lean meat diets falls far short of that of vegetarian diets. Archives of Internal Medicine 160(3): 395-396, 2000