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Use of K(L)a as a criterion for scaling up the inulinase fermentation process



Use of K(L)a as a criterion for scaling up the inulinase fermentation process



Applied biochemistry and biotechnologyng 57(57-58): 699-709



The scale-up of inulinase production in aerated cultures of Candida kefyr DSM 70106 was studied, taking into account the criterion of maintaining KLa constant. The culture was carried out batchwise, in a 15-L fermentor, with KLa varying from 25 to 199 h-1. The highest inulinase production was attained with an initial KLa value of 46 h-1. A large scale fermentation (300-L fermentor) was performed using identical culture medium conditions. The responses obtained for the bench and scaled-up experiments showed similar behaviors, and the results were, respectively, 0.60 and 0.58 U.mL-1.h-1 for productivity and 43.0 and 41.5 U.mL-1 for activities.

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