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A candidate U1 small nuclear RNA for trypanosomatid protozoa

A candidate U1 small nuclear RNA for trypanosomatid protozoa

Journal of Biological Chemistry 274(34): 23691-23694

ISSN/ISBN: 0021-9258

PMID: 10446125

DOI: 10.1074/jbc.274.34.23691

In the Trypanosomatidae, all messenger RNAs (mRNAs) obtain identical 5'-ends by trans-splicing of the 5'-terminal 39 nucleotides of a small spliced leader RNA to appropriate acceptor sites in pre-mRNA. Although this process involves spliceosomal small nuclear RNAs (snRNAs), it was thought that trypanosomatids did not contain a homologue of the cis-spliceosomal U1 snRNA.

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Accession: 003018523

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