EurekaMag.com logo
+ Translate

A statistically robust variance-components approach for quantitative trait linkage analysis


, : A statistically robust variance-components approach for quantitative trait linkage analysis. Annals of Human Genetics 63(3): 249-262

Generalized maximum likelihood estimators (M-estimators) were used to accommodate outliers in the variance-components approach to linkage analysis developed by Amos (see Amos, C. I., American Journal of Human Genetics (1994) 54, 535-543).

Accession: 003027150

DOI: 10.1046/j.1469-1809.1999.6330249.x

Download PDF Full Text: A statistically robust variance-components approach for quantitative trait linkage analysis


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Wang, J.; Guerra, R.; Cohen, J., 2000: A statistically robust variance-components approach for quantitative trait linkage analysis. Previously we showed (Wang, Guerra & Cohen 1998) that a statistically robust version of the Haseman & Elston (1972) sib-pair method greatly increased power to detect linkage in the presence of outliers. In this paper we report on M-estimat...

Goring, H.H.H.; Terwilliger, J.D.; Blangero, J., 2000: Genome scans for quantitative trait loci using variance components linkage analysis Upward bias in heritability estimates attributable to individual quantitative trait loci at lod score peaks. American Journal of Human Genetics 67(4 Supplement 2): 218, October

Johnson, M.P.; Fitzpatrick, E.; Dyer, T.D.; Jowett, J.B.M.; Brennecke, S.P.; Blangero, J.; Moses, E.K., 2006: Identification of two novel quantitative trait loci for pre-eclampsia susceptibility on chromosomes 5q and 13q using a variance components-based linkage approach. Pre-eclampsia/eclampsia (PE/E) is a common and serious disorder of human pregnancy that is associated with substantial maternal and perinatal morbidity and mortality. The suspected aetiology of PE/E is complex, with susceptibility being attributab...

Pratt, S.C.; Daly, M.J.; Kruglyak, L., 2000: Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. Methods based on variance components are powerful tools for linkage analysis of quantitative traits, because they allow simultaneous consideration of all pedigree members. The central idea is to identify loci making a significant contribution to t...

Goldgar, D.E., 1982: Partitioning the genetic variance of a quantitative trait to specific chromosomes: an alternative approach to quantitative linkage analysis. Under reasonable assumptions regarding chiasma frequency and distribution, the expected value, variance and distribution of the genetic correlation between 2 sibs on a chromosome arm was derived as a function of their identity status at marker loc...

Chen, W.M.; Broman, K.W.; Liang, K.Y., 2003: Unification of variance components and Haseman-Elston regression for quantitative trait linkage analysis in humans. American Journal of Human Genetics 73(5): 607, November

Purcell, S.; Sham, P., 2003: Variance components models for gene-environment interaction in quantitative trait locus linkage analysis. Gene-environment interaction (G x E) is likely to be a common and important source of variation for complex behavioral traits. Gene-environment interaction, or genetic control of sensitivity to the environment, can be incorporated into variance co...

Williams, J.T.; Blangero, J., 1999: Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples. We compared the statistical performance of sibpair-based and variance components approaches to multipoint linkage analysis of a quantitative trait in unselected samples. As a benchmark dataset, we used the simulated family data from Genetic Analys...

Chen, W-Min.; Broman, K.W.; Liang, K-Yee., 2004: Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression. Two of the major approaches for linkage analysis with quantitative traits in humans include variance components and Haseman-Elston regression. Previously, these were viewed as quite separate methods. We describe a general model, fit by use of gene...

Williams, J.T.; Duggirala, R.; Blangero, J., 1997: Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees. We investigated the statistical properties of a variance components method for quantitative trait linkage analysis using nuclear families and extended pedigrees.