EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Alpha- but not beta-adrenergic receptors mediate the effect of angiotensin II in the medial preoptic area on gonadotropin and prolactin secretion


European Journal of Endocrinology 138(5): 583-586
Alpha- but not beta-adrenergic receptors mediate the effect of angiotensin II in the medial preoptic area on gonadotropin and prolactin secretion
The aim of this work was to study the participation of alpha- and beta-adrenergic receptors on the effect of microinjection of angiotensin II (A II) into the medial preoptic area (MPOA) on the secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) in estrogen-primed ovariectomized (OVX) rats. Microinjection of A II into the MPOA increased plasma LH. This effect was reduced by previous microinjection of an alpha- (phentolamine), but not a beta- (propranolol) adrenergic blocker into the MPOA. Plasma PRL decreased after microinjection of A II into the MPOA, but this effect was unchanged by phentolamine or propranolol. There was no change in plasma FSH in any condition. These results indicate that A II in the MPOA stimulates LH secretion and inhibits PRL secretion in estrogen-primed OVX rats. The effect on secretion of LH, but not of PRL, is mediated by alpha-adrenergic receptors in the MPOA.


Accession: 003035665

PMID: 9625373

DOI: 10.1530/eje.0.1380583



Related references

Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion. Physiological Research 57(1): 109-118, 2007

Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion. Physiological Research 57(1): 109-118, 2008

Role of substance P in the medial preoptic area in the regulation of gonadotropin and prolactin secretion in normal or orchidectomized rats. Neuroendocrinology 51(6): 675-682, 1990

Action of AT1 subtype angiotensin II receptors of the medial preoptic area on gonadotropins and prolactin release. Neuropeptides 32(1): 51-55, 1998

Action of AT1 subtype angiotensin II receptors of the medial preoptic area on gonadotropins and prolactin release. Neuropeptides. 32(1): 51-55,., 1998

Alpha-1 adrenergic receptors in the medial preoptic area are involved in the induction of sleep. Neurochemical Research 31(8): 1095-1102, 2006

Involvement of serotonin 5HT1 and 5HT2 receptors and nitric oxide synthase in the medial preoptic area on gonadotropin secretion. Brain Research Bulletin 63(3): 243-251, 2004

Lack of effect of noradrenergic denervation of the hypothalamus and medial preoptic area on the feedback regulation of gonadotropin secretion and the estrous cycle of the rat. Endocrinology 103(2): 559-566, 1978

Effects of alpha-2-adrenergic drugs in the medial preoptic area and medial basal hypothalamus of lordosis in the guinea pig. Brain Research 628(1-2): 26-30, 1993

Effects of alpha-2-adrenergic drugs in the medial preoptic area and medial basal hypothalamus on lordosis in the guinea pig. Brain Research 628(1-2): 26-30, 1993