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An efficient and scalable method for the isolation of costatolide, a naturally-occurring anti-HIV agent, from the latex of Calophyllum teysmannii var. inophylloide






Pharmaceutical Biology 37(1): 71-76

An efficient and scalable method for the isolation of costatolide, a naturally-occurring anti-HIV agent, from the latex of Calophyllum teysmannii var. inophylloide

An efficient and scalable method is reported for the isolation of costatolide, a naturally-occurring and HIV-1-specific non-nucleoside reverse transcriptase inhibitor, from the latex of C. teysmannii var. inophylloide (from Malaysia). An overall yield of 10.6% of costatolide, with a purity of 96%, was obtained by repetitive recrystallization of the latex from a single organic solvent, subsequent to the pre-treatment of latex with hexane and dichloromethane to remove undesirable oily material.


Accession: 003037865

DOI: 10.1076/phbi.37.1.71.6326



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