Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite

Interaction of artemisinin with malarial hemeglobin catabolism and heme polymerisation. American Journal of Tropical Medicine & Hygiene 61(3 SUPPL ): 157, Sept, 1999

Effect of antifungal azoles on the heme detoxification system of malarial parasite. Journal of Biochemistry 131(3): 437-444, 2002

Heme polymerization by malarial parasite: a potential target for antimalarial drug development. Current Science (Bangalore). 10 November; 759: 911-918, 1998

Applying malaria parasite's heme detoxification system for screening potential antimalarial drugs. Analytical Biochemistry 312(2): 258-260, 2003

Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates. Journal of Medicinal Chemistry 45(19): 4321-4335, 2002

In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins. Antimicrobial Agents and ChemoTherapy 44(10): 2836-2841, 2000

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin. Journal of Medicinal Chemistry 39(22): 4511-4514, 1996

Hemin modified carbon fat electrode for analyzing antimalarial endoperoxide artemisinin in Artemisia annua. Electroanalysis 20(14): 1549-1555, 2008

Metabolism of the malarial parasite; action of antimalarial agents upon separated Plasmodium lophurae and upon certain isolated enzyme systems. Federation Proceedings 5: 400-405, 2014

Novel endoperoxide antimalarials: synthesis, heme binding, and antimalarial activity. Journal of Medicinal Chemistry 47(7): 1833-1839, 2004

Hemoglobin catabolism and host-parasite heme balance in chloroquine-sensitive and chloroquine-resistant Plasmodium berghei infections. American Journal of Tropical Medicine and Hygiene 48(4): 465-472, 1993

Alkylation of heme by the antimalarial drug artemisinin. Chemical Communications: 414-415, 2002

Novel endoperoxide antimalarias Synthesis, heme-binding, membrane, and antimalarial activity. Experimental Parasitology 105(1): 62, 2003

Extracellular heme enhances the antimalarial activity of artemisinin. Biological & Pharmaceutical Bulletin 35(1): 29-33, 2012

The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents. Expert Opinion on Investigational Drugs 14(9): 1117-1128, 2005