EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite


, : Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite. Journal of Biological Chemistry 274(27): 19383-8

Inhibition of digestive vacuole proteolytic activity of Plasmodium yoelii nigeriensis by artemisinin was observed in vitro. These observations were further confirmed by ex vivo experiments showing accumulation of haemoglobin in the parasites treated with artemisinin, suggesting inhibition of haemoglobin degradation. Artemisinin was a potent inhibitor of haem polymerization activity mediated by P. yoelii lysates as well as P. falciparum histidine-rich protein II.


Accession: 003046473

PMID: 10383451

DOI: 10.1074/jbc.274.27.19383

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Pandey, A.V.; Chauhan, V.S., 1999: Interaction of artemisinin with malarial hemeglobin catabolism and heme polymerisation. American Journal of Tropical Medicine & Hygiene 61(3 SUPPL ): 157, Sept

Huy, N.Tien.; Kamei, K.; Kondo, Y.; Serada, S.; Kanaori, K.; Takano, R.; Tajima, K.; Hara, S., 2002: Effect of antifungal azoles on the heme detoxification system of malarial parasite. The antimalarial activities of some antifungal azole agents (ketoconazole, miconazole and clotrimazole) have been known for several years, however, their antimalarial mechanism remains equivocal. Our recent study showed that clotrimazole has a rel...

Vikram Pandey, A..; Singh Chauhan, V.., 1998: Heme polymerization by malarial parasite: a potential target for antimalarial drug development. This review discusses: haemozoin formation by Plasmodium; haemozoin and the antimalarial action of quinolones; histidine-rich proteins and haem polymerization; mechanism of haem polymerization.

Sahal, D.; Kannan, R.; Chauhan, V.S., 2003: Applying malaria parasite's heme detoxification system for screening potential antimalarial drugs. Analytical Biochemistry 312(2): 258-260

Avery, M.A.; Alvim-Gaston, M.; Vroman, J.A.; Wu, B.; Ager, A.; Peters, W.; Robinson, B.L.; Charman, W., 2002: Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates. On the basis of earlier reported quantitative structure-activity relationship studies, a series of 9beta-16-(arylalkyl)-10-deoxoartemisinins were proposed for synthesis. Several of the new compounds 7 and 10-14 were synthesized employing the key s...

Benoit-Vical, F.; Robert, A.; Meunier, B., 2000: In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins. The in vitro potentiation of artemisinin by synthetic manganese porphyrin complexes has been recently reported. Since the activity of artemisinin and synthetic antimalarial endoperoxides is related to their interaction with haem, an improvement of...

O'Neill, P.M.; Bishop, L.P.; Storr, R.C.; Hawley, S.R.; Maggs, J.L.; Ward, S.A.; Park, B.K., 1996: Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin. Several artemisinin derivatives linked to benzylamino and alkylamino groups were synthesized in order to enhance accumulation within the malaria parasite. The in vitro antimalarial activity was assessed against the chloroquine sensitive HB3 strain...

Debnath, C.; Saha, P.; Ortner, A., 2008: Hemin modified carbon fat electrode for analyzing antimalarial endoperoxide artemisinin in Artemisia annua. A hemin bulk modified carbon electrode with Adeps neutralis (solid fat) as binder was developed for the determination of antimalarial endoperoxide artemisinin in plant matrix. The hemin modified electrode showed significant catalytic activity for...

Hellerman, L.; Bovarnick, M.R.; Porter, C.C., 2014: Metabolism of the malarial parasite; action of antimalarial agents upon separated Plasmodium lophurae and upon certain isolated enzyme systems. Federation Proceedings 5: 400-405

Taylor, D.K.; Avery, T.D.; Greatrex, B.W.; Tiekink, E.R.T.; Macreadie, I.G.; Macreadie, P.I.; Humphries, A.D.; Kalkanidis, M.; Fox, E.N.; Klonis, N.; Tilley, L., 2004: Novel endoperoxide antimalarials: synthesis, heme binding, and antimalarial activity. We report the synthesis of a series of novel epoxy endoperoxide compounds that can be prepared in high yields in one to three steps from simple starting materials. Some of these compounds inhibit the growth of Plasmodium falciparum in vitro. Struc...