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Artemisinine and its derivatives


, : Artemisinine and its derivatives. Indian Pediatrics 34(9): 813-816

The increasing resistance of Plasmodium falciparum to commonly-used antimalarials is discussed, and the current status of artemisinin in the treatment of malaria in India is reviewed.


Accession: 003046474

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Related references

Mi, J.F., 1991: Studies on circular dichroism of some reactional intermediates of artemisinine and artemisinine in B. This paper reports circular dichroism, sector and the olefin octant projection of 6-pair synthetic intermediates of qinghaosu (artemisinine) and qinghaosu B (artemisinine B): gamma-lactone (compounds 1-4, 7-10), delta-lactone (compounds 5-6) and e...

Scheiwe, Max Werner, 2001: Pharmaceutically active composition containing artemisinine and/or derivative of artemisinine. The invention relates to a pharmaceutically active composition containing a substance which is active against malaria parasites and shows a high level of activity against multiresistant lines of Plasmodium falciparum. The inventive composition is...

Gera, R.; Khalil, A., 1998: Artemisinine and its derivatives. Indian Pediatrics 34(9): 813-816

Li, Y. et al., 1979: Synthesis of some derivatives of artemisinine. Over 30 derivatives of artemisinine (qinghaosu) were synthesised and evaluated against a chloroquine-resistant strain of Plasmodium berghei in mice. Many of the compounds were much more potent than artemisinine.

Guan, W.B.; Huang, W.J.; Zhou, Y.C.; Gong, J.Z., 1982: Effect in vitro of artemisinine and its derivatives on Plasmodium falciparum. Plasmodium falciparum, in vitro, growth inhibited by addition of artemisinine or its derivatives, sodium artesunate most effective

Li, W.H.; Shu, H.L.; Xu, G.Y.; Zeng, Y.L., 1982: The binding of qinghaosu (artemisinine) and its derivatives to plasma protein. Yao Xue Xue Bao 17(10): 783-786

Y.L.n; Chen Y X.; W.J.; J.R., 1981: Synthesis and evaluation of anti malarial artemisinine derivatives. Abstracts of Papers American Chemical Society 182: SORT 23

Wang, Z.S.; Zhu, Y.H.; Zhang, S.L.; Liu, X.L., 1981: Determination of artemisinine and its derivatives by high pressure liquid chromatography. Yao Xue Xue Bao 16(6): 466-470

Gu, H.M.; Lu, B.F.; Qu, Z.X., 1980: Antimalarial activity of 25 derivatives of artemisinine against chloroquine-resistant Plasmodium berghei. The activities of 25 derivatives of artemisinine (qinghaosu) were determined against a chloroquine-resistant strain of Plasmodium berghei in mice. Many of the derivatives were more potent than the parent compound. 4 carbonates had SD 90 values (90...

G.H.M.; L.B.F.; Q.Z.X., 1980: Anti malarial activities of 25 derivatives of artemisinine against chloroquine resistant plasmodium berghei. The antimalarial activities of 25 derivatives of artemisinine, including dihydroartemisinine, 13 ethers, 6 esters and 5 carbonates, were compared. Each compound, dissolved in tea seed oil, was injected i.m. into mice infected with the chloroquine-...