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Atovaquone and proguanil hydrochloride for prophylaxis of malaria



Atovaquone and proguanil hydrochloride for prophylaxis of malaria



Journal of Travel Medicine 6(Supplement 1): S21-S27



The results of clinical trials that evaluated either a fixed-dose combination of atovaquone and proguanil hydrochloride for malaria prophylaxis or atovaquone alone for causal prophylactic activity against Plasmodium falciparum are reviewed. In 3 placebo-controlled trials, 331 subjects received 250 mg atovaquone and 100 mg proguanil hydrochloride (or an equivalent dose based on body weight in children) once daily for 10 to 12 weeks. The overall efficacy for preventing parasitaemia was 98%.

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Accession: 003048729

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