Section 4
Chapter 3,074

Comparison of a new triazole antifungal agent, Schering 56592, with itraconazole and amphotericin B for treatment of histoplasmosis in immunocompetent mice

Connolly, P.; Wheat, J.; Schnizlein-Bick, C.; Durkin, M.; Kohler, S.; Smedema, M.; Goldberg, J.; Brizendine, E.; Loebenberg, D.

Antimicrobial Agents and ChemoTherapy 43(2): 322-328


ISSN/ISBN: 0066-4804
PMID: 9925526
Accession: 003073894

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A murine model of intratracheally induced Histoplasma capsulatum infection was used to evaluate Schering (SCH) 56592 for treatment of histoplasmosis. Minimum inhibitory concentrations (MICs) were determined for SCH 56592, amphotericin B and itraconazole by testing yeast-phase isolates from 20 patients by a macrobroth dilution method.

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