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Effect of Perilla frutescens extract on nitric oxide production by cultured murine mesangial cells


Effect of Perilla frutescens extract on nitric oxide production by cultured murine mesangial cells



Biological and Pharmaceutical Bulletin 22(5): 476-480



ISSN/ISBN: 0918-6158

PMID: 10375167

DOI: 10.1248/bpb.22.476

The effect of a water extract of P. frutescens leaves on nitric oxide (NO) production by cultured murine mesangial cells was investigated. The extract significantly induced NO production from mesangial cells, which was enormously augmented without cytotoxicity by combination with interferon (IFN)- gamma or tumour necrosis factor- alpha. The extract suppressed a large amount of NO production induced by IFN- gamma combined with lipopolysaccharide.

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Accession: 003104241

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