+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of branched-chain-enriched amino acid solution on insulin and glucagon secretion and blood glucose level in liver cirrhosis



Effects of branched-chain-enriched amino acid solution on insulin and glucagon secretion and blood glucose level in liver cirrhosis



Scandinavian Journal of Gastroenterology 33(8): 853-859



Background: The aim of this study was to determine whether therapeutically used branched-chain amino acids (BCAAs) solution influences glucose metabolism in liver cirrhosis (LC). Methods: BCAAs solution (200 ml) was infused in LC patients at different stages, and plasma concentrations of glucose and pancreatic hormones were determined. Results: In patients with mild LC, BCAAs caused a significant increase in glucose level (maximal increment, 12.5 +- 2.5 mg/dl) with a great increase in insulin (maximal increment, 39.5 +- 8.3 muU/ml) and a small increase in glucagon secretion (maximal increment, 101.0 +- 16.0 pg/ml). In patients with advanced LC, BCAAs caused a great increase in glucagon secretion (220.5 +- 19.4 pg/ml) with only a slight increase in glucose levels (5.8 +- 2.2 mg/dl). Conclusion: BCAAs solution causes hyperglycemia in mild LC due to insulin resistance, whereas it causes only a slight increase in severe LC due to hepatic glucagon resistance. Thus, there is a possibility that BCAAs solution may lead to hypoglycemia in advanced LC with hepatic glycogen depletion.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003116660

Download citation: RISBibTeXText

PMID: 9754734

DOI: 10.1080/00365529850171521


Related references

Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 3. effects of administration of short chain fatty acid on blood branched chain amino acid concentrations in rats. Acta Scholae Medicinalis Universitatis in Gifu 29(4): 642-651, 1981

Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 2. effects of administration of ammonia on blood branched chain amino acid concentrations in rats. Acta Scholae Medicinalis Universitatis in Gifu 29(4): 630-641, 1981

Nutritional status in hepatocellular carcinoma associated with liver cirrhosis effect of intravenous administration of branched chain amino acid enriched solution. Journal of Clinical Biochemistry & Nutrition 7(3): 251-262, 1989

Branched-chain amino acid-enriched diet: effects on insulin secretion and cellular immune aggression. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 224(3): 159-165, 2000

Effect of an amino acid solution and amino acids granules enriched with branched chain amino acids on the blood ammonia level. Ogoshi, S And A Okada (Ed ) Excerpta Medica International Congress Series, No 649 Parenteral And Enteral Hyperalimentation; International Symposium, Kochi, Japan, Nov 16-17, 1983 Xv+376p Excerpta Medica: Amsterdam, Netherlands; New York, N Y , Usa; Elsevier Science Publishers B V : Amsterdam, Netherlands (Dist in The Usa And Canada By Elsevier Science Publishing Co Inc : New York, N Y , Usa) Illus 248-266, 1984, 1985, 1986

Effects of branched-chain amino acids solution on cerebral blood flow in patients with liver cirrhosis. Journal of Nuclear Medicine 44(5 Suppl.): 228P-229P, 2003

Lowering effect of branched chain amino acid and arginine on blood ammonia level in patients with liver cirrhosis. Gastroenterology 108(4 Suppl. ): A1105, 1995

Anticatabolic effect of branched-chain amino acid-enriched solutions in patients with liver cirrhosis. Hepatology 2(4): 420-425, 1982

Nutritional treatment of liver cirrhosis by branched-chain amino acid-enriched nutrient mixture. Journal of Nutritional Science and Vitaminology 31(3): 291-303, 1985

Effects of an amino acid solution enriched with either branched chain amino acids or ornithine-alpha-ketoglutarate on the postoperative intracellular amino acid concentration of skeletal muscle. British Journal of Surgery 77(2): 214-218, 1990

Beneficial effects of branched-chain amino acids on altered protein and amino acid metabolism in liver cirrhosis: evaluation in a model of liver cirrhosis induced in rats with carbon tetrachloride. Hepatology Research 27(2): 117-123, 2003

Branched chain enriched amino acid versus glucose treatment of hepatic encephalopathy. A double-blind study of 65 patients with cirrhosis. Journal of Hepatology 10(3): 291-296, 1990

Effects of branched chain amino acid and arginine enriched amino acid solution on brain regional amine metabolism. Japanese Journal of Pharmacology 49(Suppl.): 110P, 1989

Effects of branched-chain amino acid granules on serum albumin level and prognosis are dependent on treatment adherence in patients with liver cirrhosis. Hepatology Research 43(5): 459-466, 2013

Effect of insulin resistance on peripheral metabolism of glucose and branched chain amino acids in liver cirrhosis. Rivista Italiana di Nutrizione Parenterale ed Enterale 4(3): 139-144, 1986