EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Epidemiology and in vitro activity of antimycotics against candidal vaginal/skin/nail infections in Singapore






International Journal of Dermatology 37(2): 145-149

Epidemiology and in vitro activity of antimycotics against candidal vaginal/skin/nail infections in Singapore

Background: Candidal infections of the skin/nails and vagina are very common worldwide. Various in vitro test systems are available to help to determine the antifungal activity of drugs. The minimum inhibitory concentration (MIC) is a standard measure of the in vitro potency of drugs against yeasts. Methods: Vaginal smears and skin/nail scrapings of 50 consecutive patients with candidal vaginitis and 46 consecutive patients (28 women, 18 men) with cutaneous/nail candidosis were used in the study. Direct microscopy and culture from vaginal smears and skin scrapings were performed on all patients. The MICs were determined using the broth dilution method. Results: For vaginal candidosis, the mean age of the patients was 28.2 years (range, 9-49 years). Candida albicans accounted for 58% of the isolates, C. glabrata for 32%, C. tropicalis for 6%, and C. parasilosis for 4%. At the MIC of ltoreq4 mg/L, 65-95% of C. albicans, 66-94% of C. glabrata, 33-100% of C. tropicalis, and 0-50% of C. parasilosis were susceptible to the drugs tested (ketoconazole, itraconazole, nystatin, amorolfine, clotrimazole, and miconazole). For cutaneous/nail candidosis, the mean age of the patients was 45 years (range, 19-82 years). C. albicans made up 59% of the isolates, C. parasilosis 20%, C. krusei 13%, C. glabrata 4%, and C. tropicalis 4%. At the MIC of ltoreq4 mg/L, 59-960/. of C. albicans, 100% of C. glabrata, 83-100% of C. krusei, 89-100% of C. parasilosis, and 100% of C. tropicalis were susceptible to the drugs tested (ketoconazole, itraconazole, nystatin, amorolfine, clotrimazole, and miconazole). Conclusions: C. albicans is the most common Candida species causing cutaneous/nail and vaginal candidosis in Singapore. The in vitro antifungal activities of ketoconazole, itraconazole, nystatin, amorolfine, clotrimazole, and miconazole are similar against the various Candida species. C. parasilosis in vaginal candidosis appears to be less susceptible. Here, itraconazole and amorolfine may be more effective.


Accession: 003127503

PMID: 9542677



Related references

Oral candidal infections and antimycotics. Critical Reviews in Oral Biology and Medicine 11(2): 172-198, 2002

In-vitro permeability of the human nail and of a keratin membrane from bovine hooves: Prediction of the penetration rate of antimycotics through the nail plate and their efficacy. Journal of Pharmacy and Pharmacology 49(9): 866-872, 1997

Sporicidal effect of amorolfine and other antimycotics used in the therapy of fungal nail infections. Mycoses 58(10): 610-619, 2016

The contribution of fluconazole to the changing epidemiology of invasive candidal infections. Clinical Infectious Diseases 24(6): 1129-1130, 1997

In vitro activity of tigecycline against isolates collected from complicated skin and skin structure infections and intra-abdominal infections in Africa and Middle East countries: TEST 2007-2012. Diagnostic Microbiology and Infectious Disease 79(1): 54-59, 2015

In vitro activity of meropenem against organisms causing serious infections in a Singapore hospital. International Journal of Antimicrobial Agents 9(2): 121-125, 2008

In vitro activity of meropenem against organisms causing serious infections in a Singapore hospital. International Journal of Antimicrobial Agents 9(2): 121-125, Sept, 1997

In vitro activity of tigecycline against isolates from patients enrolled in phase 3 clinical trials of treatment for complicated skin and skin-structure infections and complicated intra-abdominal infections. Clinical Infectious Diseases 41 Suppl 5: S315-S332, 2005

Epidemiology of skin disease among children in a referral skin clinic in Singapore. Pediatric Dermatology 11(2): 125-128, 1994

Skin candidal granuloma complicated by candidal cervical lymphadenitis: a case report. Journal of Clinical Dermatology 32(12): 724-725, 2003