EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Epinephrine produces a prolonged elevation in metabolic rate in humans



Epinephrine produces a prolonged elevation in metabolic rate in humans



American Journal of Clinical Nutrition 68(5): 1046-1052



Background: Epinephrine increases the metabolic rate and contributes to the hypermetabolic state in severe illness. Objective: We sought to determine the effect of prolonged elevation of epinephrine on resting energy expenditure (REE). Design: Thirteen healthy men were placed on a well-defined diet for 5 d. Beginning on the morning of the second diet day, the subjects were infused for 24 h with saline, then for 23 h with epinephrine (0.18 nmol cntdot kg-1 cntdot min-1) to increase plasma epinephrine concentrations into the high physiologic range (4720 +- 340 pmol/L). REE and the respiratory quotient (RQ) were measured by indirect calorimetry in the postabsorptive state at the same time every morning. Results: Infusion of epinephrine significantly increased heart rate and systolic blood pressure, but the response was transient (values after 23 h of epinephrine infusion were not significantly different from those on the day saline was infused). Infusion of epinephrine significantly increased REE by 12% and increased the RQ. These changes were apparent at the end of the 23-h infusion (REE: 97.5 +- 2.3 kJcntdotkg-1cntdotd-1 with saline infusion and 108.9 +- 2.3 kJcntdotkg-1cntdotd-1 with epinephrine infusion; RQ: 0.832 +- 0.012 with saline infusion and 0.879 +- 0.013 with epinephrine infusion). REE returned to baseline by 24 h after the epinephrine infusion ended, but the postabsorptive RQ remained modestly elevated. Infusion of epinephrine also produced a transient increase in urine flow and in urinary nitrogen excretion. This diuresis was compensated for by a drop in urine volume and nitrogen excretion after the epinephrine infusion was stopped. Conclusions: Epinephrine produced a prolonged increase in REE in healthy subjects. The fuel for this increase in RFE, determined by the RQ, was from increased carbohydrate oxidation, not from that of fat or protein.

(PDF 0-2 workdays service: $29.90)

Accession: 003127737

Download citation: RISBibTeXText

PMID: 9808221



Related references

Physiological increments in epinephrine stimulate metabolic rate in humans. American Journal of Physiology 253(3 Pt 1): E322-E330, 1987

Prolonged elevation in metabolic rate following meal exercise challenge in anorexic patients undergoing refeeding. American Journal of Clinical Nutrition 47(4): 776, 1988

Preservation of the ratio of cerebral blood flow/metabolic rate for oxygen during prolonged anesthesia with isoflurane, sevoflurane, and halothane in humans. Anesthesiology (Hagerstown) 84(3): 555-561, 1996

Liposomal Bupivacaine Produces Prolonged Analgesia in Humans. Anesthesiology Abstracts of Scientific Papers Annual Meeting (2001): Abstract No A-926, 2002

Brief exposure to endotoxin produces prolonged endothelial dysfunction in humans. Clinical Science (London) 90(2): 22P, 1996

Prolonged Elevation Of Serum Free Fatty Acids Following Epinephrine Administration To Patients With Glycogenosis. Israel Journal of Medical Sciences 1: 84-86, 1965

Periaqueductal gray stimulation in humans produces analgesia accompanied by elevation of beta-endorphin and ACTH in ventricular CSF. Modern Problems of Pharmacopsychiatry 17: 109-122, 1981

Adverse effects of opioid analgesic treatment are correlated with a significant elevation in plasma epinephrine in healthy humans. European Journal of Clinical Pharmacology 56(6-7): 463-468, September, 2000

Metabolic stress produces rapid immunosuppression in humans. Archives of General Psychiatry 44(12): 1108-1109, 1987

Prolonged sympathoinhibition following sustained elevation of arterial pressure in humans. Hypertension (Dallas) 17(3): 419, 1991

Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. American Journal of Physiology 276(6 Pt 1): E1055-E1066, 1999

Peri aqueductal gray stimulation in humans produces analgesia accompanied by elevation of beta endorphin and acth in ventricular cerebro spinal fluid. Emrich, H M (Ed ) Modern Problems Of Pharmacopsychiatry, Vol 17 The Role Of Endorphins in Neuropsychiatry Vii+290p S Karger: Basel, Switzerland; New York, N Y , Usa Illus P109-122, 1981, 1982

Plasma epinephrine and rate pressure product elevation during helicopter transport of cardiac patients. Circulation 78(4 PART 2): II188, 1988

Fat cell number, resting metabolic rate, mean heart rate, and insulin elevation while seeing and smelling food as predictors of slimming. Metabolism: Clinical and Experimental 29(11): 1003-1012, 1980