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Evaluation of proliferative activity of the mammary gland tumours in dogs by the number of mitoses and PCNA immunoreactive cells



Evaluation of proliferative activity of the mammary gland tumours in dogs by the number of mitoses and PCNA immunoreactive cells



Zbornik Veterinarske Fakultete Univerza Ljubljana 36(1): 43-56



Cell protein PCNA (proliferative cell nuclear antigen) and the number of mitoses were assessed in different mammary gland tumours of dogs. PCNA was detected immunohistochemically (clone PC10, Dako), and the number of mitoses was measured using mitotic activity index (MAI). Tumours were divided in 5 groups: malignant glandular tumours (carcinomas, adenocarcinomas) of simple or complex type, benign tumours, dysplasia and other tumours.

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