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Expression of milk protein genes is induced directly by exogenous STAT5 without prolactin-mediated signal transduction in transgenic mice



Expression of milk protein genes is induced directly by exogenous STAT5 without prolactin-mediated signal transduction in transgenic mice



Molecular Reproduction and Development 54(2): 121-125



This study examined the feasibility of activating STAT5 (a member of the signal transducer for activating transcription family) expression in vivo using transgenic mice overexpressing ovine STAT5 (oSTAT5) under the control of the MMTV promoter. Three transgenic mouse lines that expressed the introduced oSTAT5 in their mammary glands were established. In the mammary glands of all 3 lines, the expression level of oSTAT5 was higher than that of endogenous STAT5.

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Accession: 003136882

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PMID: 10471471

DOI: 10.1002/(sici)1098-2795(199910)54:2<121::aid-mrd3>3.0.co;2-t


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