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Fine-mapping of quantitative trait loci by identity by descent in outbred populations: application to milk production in dairy cattle


Fine-mapping of quantitative trait loci by identity by descent in outbred populations: application to milk production in dairy cattle



Proceedings of the National Academy of Sciences of the United States of America 96(16): 9252-9257



ISSN/ISBN: 0027-8424

PMID: 10430929

DOI: 10.2307/48307

The fine mapping of a quantitative trait locus (QTL) on chromosome 14 affecting milk production in dairy cattle is reported. Seven sires that were heterozygous for the QTL were identified in a Holstein-Friesian pedigree comprised of 1,158 animals by marker-assisted segregation analysis. The 7 selected sires were then genotyped using 9 microsatellites and 3 single nucleotide polymorphisms and analyzed for the presence of a shared haplotype that flanked a hypothetical, identical-by-descent QTL allele with large substitution effect. The 7 chromosomes increasing milk fat percentage carried a common region of about 5 cM that was predicted to contain the QTL, and the same haplotype was linked to increased fat percentage in the general population.

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Accession: 003141853

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