+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450



Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450



Antimicrobial Agents and ChemoTherapy 43(5): 1163-1169



The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of C. albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. 12 nucleotide substitutions, resulting in 4 amino acid changes, were identified in the DUMC136 CYP51 gene in comparison with a reported CYP51 sequence from a wild-type, fluconazole-susceptible C. albicans strain.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 003145900

Download citation: RISBibTeXText

PMID: 10223930


Related references

Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450. Antimicrobial Agents and Chemotherapy 43(5): 1163-1169, 1999

Effects of Y132H and F145L substitutions on the activity, azole resistance and spectral properties of Candida albicans sterol 14-demethylase P450 (CYP51): a live example showing the selection of altered P450 through interaction with environmental compounds. Journal of Biochemistry 137(5): 625-632, 2005

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. Journal of Biological Chemistry 292(16): 6728-6743, 2017

Emergence of fluconazole-resistant sterol 14-demethylase P450 in Candida albicans is a model demonstrating the diversification mechanism of P450. Archives of Biochemistry & Biophysics 379(1): 170-171, July 1, 2000

Emergence of fluconazole-resistant sterol 14-demethylase P450 (CYP51) in Candida albicans is a model demonstrating the diversification mechanism of P450. Archives of Biochemistry and Biophysics 379(1): 170-171, 2000

Cytochrome P -450-dependent 14-sterol demethylase of Candida albicans and its interaction with azole antifungals. Biochemical Society Transactions 19(3): 782-787, 1991

Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrobial Agents and ChemoTherapy 54(10): 4235-4245, 2011

Inhibition of 14 -sterol demethylase activity in Candida albicans Darlington does not correlate with resistance to azole. Medical Mycology 25(5): 329-333, 1987

Cytochrome P-450-dependent 14 alpha -sterol demethylase of Candida albicans and its interaction with azole antifungals. Biochemical Society Transactions 19(3): 782-787, 1991

Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and ChemoTherapy 57(3): 1352-1360, 2013

Inhibition of 14 alpha-sterol demethylase activity in Candida albicans Darlington does not correlate with resistance to azole. Journal of Medical and Veterinary Mycology 25(5): 329-333, 1987

Interaction of azole antifungal antibiotics with cytochrome P -450-dependent 14-sterol demethylase purified from Candida albicans. Biochemical Journal 266(2): 475-480, 1990

Azole Affinity of Sterol 14alpha-Demethylase CYP51 Enzymes from Candida albicans and Homo sapiens. 2013

The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions. Antimicrobial Agents and ChemoTherapy 2019, 2019

Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans. Biochemical Journal 266(2): 475-480, 1990