+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ginseng improves strategic learning by normal and brain-damaged rats

Ginseng improves strategic learning by normal and brain-damaged rats

Neuroreport 9(7): 1619-1624

Adult rats were prepared with either sham or medial prefrontal cortex lesions and administered, beginning on the third post-operative day, either, 0, 40, or 80 mg kg-1 crude ginseng extract suspended in saline daily for the next 30 days. Later, kinetic functions were evaluated on an elevated rotating rod. No long-term influences of the treatments were observed on this task. Significant positive influences of ginseng were observed in the position reversal task. The learning deficits observed in the saline control brain-damaged rats were significantly attenuated in the ginseng-treated animals. An analysis of trial 2 response accuracy across reversals revealed enhanced cognitive abilities (i.e. acquisition of a win-stay, lose-shift strategy) in both the brain damaged and sham control rats administered ginseng. Generally, administration of the higher dose resulted in better performance in the learning paradigm. The exact mechanism responsible for these promising results remains to be discovered. Several possible mechanisms are discussed.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 003153904

Download citation: RISBibTeXText

PMID: 9631476

DOI: 10.1097/00001756-199805110-00066

Related references

AVP (4-8) improves concept learning in PFC-damaged but not hippocampal-damaged rats. Brain Research 919(1): 41-47, 2001

ACTH 4-9 analog can retard spatial alternation learning in brain damaged and normal rats. Behavioral and Neural Biology 52(2): 271-278, 1989

Impaired visual and spatial reversal learning in brain damaged rats additional components of the general learning system of the rodent brain. Physiological Psychology 10(3): 293-305, 1982

Learning and retentiveness in brain-damaged rats. Journal of Comparative and Physiological Psychology 52: 501-505, 1959

Wechsler Memory Scale paired-associate learning in discrimination of brain-damaged and non-brain-damaged psychiatric patients. Perceptual and Motor Skills 39(1): 227-230, 1974

Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats. PhytoTherapy Research 26(1): 142-147, 2012

Performance of minimally brain-damaged and normal children on a simple discrimination learning task. Dissertation Absts 21(10): 3166, 1961

Neuropsychological test findings for normal, learning-disabled, and brain-damaged young adults. Journal of Consulting and Clinical Psychology 51(5): 726-729, 1983

Lateralized sensorimotor asymmetries in normal, learning-disabled and brain-damaged young adults. Perceptual and Motor Skills 57(1): 227-232, 1983

Neuropsychological test performance of normal, learning-disabled, and brain-damaged older children. Journal of Nervous and Mental Disease 167(5): 298-302, 1979

Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. Metabolism: Clinical and Experimental 58(8): 1170-1177, 2009

Erythropoietin improves place learning in fimbria-fornix-transected rats and modifies the search pattern of normal rats. Pharmacology, Biochemistry, and Behavior 77(2): 381-390, 2004

Abnormal learning and forgetting of individual spatial reversal problems in brain damaged rats. Physiological Psychology 11(1): 35-46, 1983

Pharmacologic changes in performance of normal and brain damaged rats. Behavioral Biology 17(2): 197-211, 1976