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Host cell factor CD59 restricts complement lysis of Plasmodium falciparum-infected erythrocytes



Host cell factor CD59 restricts complement lysis of Plasmodium falciparum-infected erythrocytes



European Journal of Immunology 27(10): 2708-2713



Here we demonstrate that components of the entire complement cascade are fixed on the surface of erythrocytes infected with the human malarial parasite Plasmodium falciparum. Despite the activation of lytic complement factors, no complement-mediated lysis of parasitized erythrocytes was observed. Complement-mediated lysis of P. falciparum-infected erythrocytes occurred only in the absence of functional intrinsic CD59. These data suggest that the restriction of the complement attack of P. falciparum-infected erythrocytes is principally mediated by intrinsic host cell factors, in particular CD59.

Accession: 003161883

Download citation: RISBibTeXText

PMID: 9368630

DOI: 10.1002/eji.1830271034

Download PDF Full Text: Host cell factor CD59 restricts complement lysis of Plasmodium falciparum-infected erythrocytes



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