EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Human adult-onset lactase decline: an update






Nutrition Reviews 56(1): 1-8

Human adult-onset lactase decline: an update

Current knowledge on human adult-onset lactase decline is reviewed. This condition, which is prevalent in over half of the world's population, is characterized by a decrease in intestinal lactase enzyme activity during mid-childhood. Lactase levels, gastric emptying rate, and colonic salvage all affect the digestion and absorption of lactose. Symptoms can be alleviated in many lactose-intolerant people by commercially available "lactase" products. However, interventions that reduce the rate of gastric emptying and increase the proliferation of lactose-metabolizing bacteria in the colon could be devised if the variability of lactose tolerance was better understood. Affected individuals appear to be at increased risk for osteoporosis, and elderly people with both adult-onset lactase decline and atrophic gastritis or those undergoing anti-ulcer treatment may have a greater risk of low calcium absorption due to the lack of gastric acid that facilitates calcium uptake.

Accession: 003162754

PMID: 9481112

DOI: 10.1111/j.1753-4887.1998.tb01652.x

Download PDF Full Text: Human adult-onset lactase decline: an update



Related references

Rossi, M.; Maiuri, L.; Salvati, V.M.; Russomanno, C.; Capparelli, R.; Auricchio, S., 1993: In vitro biosynthesis of lactase in suckling and adult rabbits. Regulatory mechanisms involved in the decline of the lactase activity. Steady state forms, levels and the in vitro biosynthesis of lactase-phlorizin hydrolase (LPH) proteins have been studied in proximal and middle intestine of suckling and adult rabbits. In most adult tissues the lactase activity and the LPH protein...

Rossi, M.; Maiuri, L.; Salvati, V., M.; Russomanno, C.; Capparelli, R.; Auricchio, S., 1993: In vitro biosynthesis of lactase in suckling and adult rabbits: Regulatory mechanisms involved in the decline of the lactase activity. Steady state forms, levels and the in vitro biosynthesis of lactase-phlorizin hydrolase (LPH) proteins have been studied in proximal and middle intestine of suckling and adult rabbits. In most adult tissues the lactase activity and the LPH protein...

Flatz, Gebhard, 1992: Lactase deficiency Biologic and medical aspects of the adult human lactase polymorphism. King, Richard A , Rotter, Jerome I , Motulsky, Arno G Oxford Monographs on Medical Genetics; The genetic basis of common diseases : 305-325

Mina, R.; Brunner, H.I., 2015: Update on differences between childhood-onset and adult-onset systemic lupus erythematosus. Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. The estimated annual incidence among children is 2.22/100,000 and among adults is 23.2/100,000 in the United States. There is incr...

Asp, N.G.; Dahlqvist, A., 1974: Intestinal beta-galactosidases in adult low lactase activity and in congenital lactase deficiency. Enzyme 18(1): 84-102

Goda, T.B.stamante, S.T.ornburg, W.K.ldovsky, O., 1984: Dietary-induced icnrease in lactase activity and in immunoreactive lactase in adult rat jejunum. Biochemical journal, 221(1): 261-263

Goda, T.; Bustamante, S.; Thornburg, W.; Koldovský, O., 1984: Dietary-induced increase in lactase activity and in immunoreactive lactase in adult rat jejunum. Adult rats that had been fed on a low-starch high-fat diet for 7 days were force-fed with either the same diet or isoenergetic diets containing 40% of energy as either sucrose or lactose. Within 12h, the increase in jejunal lactase activity in suc...

Lorenzsonn, V.; Lloyd, M.; Olsen, W.A., 1993: Immunocytochemical heterogeneity of lactase-phlorizin hydrolase in adult lactase deficiency. Background: Adult lactase deficiency may result either from diminished synthesis of precursor lactase-phlorizin hydrolase (phenotype I deficiency) or from altered posttranslational processing of the precursor protein (phenotype II). The aim of thi...

Lami, F.; Callegari, C.; Tatali, M.; Graziano, L.; Guidetti, C.; Miglioli, M.; Barbara, L., 1988: Efficacy of addition of exogenous lactase to milk in adult lactase deficiency. The efficacy of lactose by Kluyveromyces lactis in hydrolyzing milk lactase and reducing milk intolerance symptoms was tested in 52 proved lactose malabsorbers. The enzyme was added to milk administered to the patients, and H2 breath excretion (as...

Maiuri, L.; Rossi, M.; Raia, V.; Paparo, F.; Garipoli, V.; Auricchio, S., 1993: Surface staining on the villus of lactase protein and lactase activity in adult-type hypolactasia. Background: We have shown in previous studies the presence of a patchy pattern of lactase protein expression in the proximal jejunum of hypolactasic humans, adult rabbits, and rats. The present study investigated the mechanisms underlying the hete...