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Human monoclonal antibodies to the V3 loop of HIV-1 with intra- and interclade cross-reactivity






Journal of Immunology 159(10): 5114-5122

Human monoclonal antibodies to the V3 loop of HIV-1 with intra- and interclade cross-reactivity

Five human anti-V3 monoclonal antibodies (mAbs) were generated from Ab-producing cells derived from the blood of HIV-1-infected individuals from North America and selected using the V3 peptide of a divergent clade B isolate, HIVRF. The anti-V3RF mAbs were mapped to a cluster of 3 overlapping epitopes present in the KSITKGP sequence located in the hypervariable region on the N-terminal side of the V3 loop.


Accession: 003162995

PMID: 9366441



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