+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Human monoclonal antibodies to the V3 loop of HIV-1 with intra- and interclade cross-reactivity

Journal of Immunology 159(10): 5114-5122

Human monoclonal antibodies to the V3 loop of HIV-1 with intra- and interclade cross-reactivity

Five human anti-V3 monoclonal antibodies (mAbs) were generated from Ab-producing cells derived from the blood of HIV-1-infected individuals from North America and selected using the V3 peptide of a divergent clade B isolate, HIVRF. The anti-V3RF mAbs were mapped to a cluster of 3 overlapping epitopes present in the KSITKGP sequence located in the hypervariable region on the N-terminal side of the V3 loop.

Accession: 003162995

PMID: 9366441

Related references

Karwowska S.; Gorny M.K.; Zolla Pazner S., 1991: Relation between cross reactivity and affinity of human monoclonal antibodies humabs to synthetic peptides of the v3 loop of divergent hiv strains. Istituto Superiore Di Sanita Vii International Conference on Aids: Science Challenging Aids; Florence, Italy, June 16-21, 464p (Vol 1); 460p (Vol 2) Istituto Superiore Di Sanita: Rome, Italy Paper : 171

Verrier, F.; Burda, S.; Belshe, R.; Duliege, A.M.; Excler, J.L.; Klein, M.; Zolla-Pazner, S., 2000: A human immunodeficiency virus prime-boost immunization regimen in humans induces antibodies that show interclade cross-reactivity and neutralize several X4-, R5-, and dualtropic clade B and C primary isolates. A human immunodeficiency virus (HIV) vaccine that will be useful in diverse geographic regions will need to induce a broad immune response characterized by cross-clade immunity. To test whether a clade B-based HIV candidate vaccine could induce in...

Palker, T.J.; Scearce, R.M.; Ho, W.; Copeland, T.D.; Oroszlan, S.; Popovic, M.; Haynes, B.F., 1985: Monoclonal antibodies reactive with human T cell lymphotropic virusI (HTLVI) p19 internal core protein: cross-reactivity with normal tissues and differential reactivity with HTLV types I and II. Three monoclonal antibodies to human T cell lymphotropic virus type I (HTLVI) p19 internal core protein, designated as alpha HTLV-2, 3, and 4, have been developed. In indirect immunofluorescence (IF) assays, these antibodies reacted with acetone-f...

Karwowska S.; Gorny M.K.; Buchbinder A.; Zolla Pazner S., 1992: Type specific human monoclonal antibodies cross react with the v3 loop of various hiv 1 isolates. Brown, F , Et Al (Ed ) Vaccines (Cold Spring Harbor), 92 Modern Approaches to New Vaccines Including Prevention Of Aids; Ninth Annual Meeting, Cold Spring Harbor, New York, Usa, September 19-23, 1991 Xxiii+408p Cold Spring Harbor Laboratory Press: Plainview, New York, Usa Illus Paper 171-174

Black, C.M.; Mcdougal, J.S.; Holman, R.C.; Evatt, B.L.; Reimer, C.B., 1993: Cross-reactivity of 75 monoclonal antibodies to human immunoglobulin with sera of non-human primates. We systematically analyzed a panel of 75 murine monoclonal antibodies (mAbs) reactive with human immunoglobulins IgG, IgA, IgM, IgD, and kappa and lambda light chains for reactivity with serum immunoglobulins of higher primates. In the great apes,...

Arriens, M.A.; Summerfield, A.; Schaffner, R.; Mccullough, K.C., 1996: Cross reactivity of anti-human CD monoclonal antibodies with porcine leukocytes. Veterinary Immunology & Immunopathology 54(1-4): 113

Chen, Z.; Lin, G.X.; Nehlsen Cannarella, S.L.; Wee, S.; Boskovic, S.; Hollemweguer, E.; Huang, E., 1996: Cross-reactivity of anti-human monoclonal antibodies with animal leukocytes. FASEB Journal 10(6): A1196

Cummings, H.S.; Ploplis, V.A.; Beals, J.M.; Castellino, F.J., 1984: Interspecies cross-reactivity of monoclonal antibodies to various epitopes of human plasminogen. The immunological cross-reactivities of three conformationally specific monoclonal antibodies to distinct epitopes on human plasminogen toward plasminogens purified from 14 additional species have been examined. Antibody 10-F-1, which is produced...

Petyaev, I.M.; Zigangirova, N.A.; Tsibezov, V.V.; Ross, A.; Bashmakov, Y.K., 2011: Monoclonal antibodies against lipopolysaccharide of Chlamydia trachomatis with cross reactivity to human ApoB. Splenocytes obtained from mice immunized with whole purified elementary bodies of Chlamydia trachomatis were used for hybridoma construction. The resulting clones were screened with ELISA using chlamydial lipopolysaccharide (LPS) and full-length h...

Brochier J.; Schmitt D., 1986: Cross reactivity of anti lymphocyte monoclonal antibodies on human skin components. Reinherz, E L Et Al (Ed ) Leukocyte Typing Ii, Vol 1 Human T Lymphocytes; 2nd International Workshop on Human Leukocyte Differentiation Antigens, Boston, Mass , Usa, Sept 17-20, 1984 Xx+549p Springer-Verlag: New York, N Y , Usa; Berlin, West Germany Illus 406-414