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Morphological investigations in experimental cases of mercuric poisoning in sheep

Morphological investigations in experimental cases of mercuric poisoning in sheep

Veterinarski Arhiv 68(5): 163-171

An experiment was carried out to reproduce chronic mercury poisoning in sheep by treating (per os) with sub-lethal doses of 1% mercuric chloride solution. Pathoanatomical and pathomorphological changes in various internal organs were studied in dynamics by using biopsy materials, as well by slaughtering of sheep during the experiment. Macroscopically, livers (extravasations) were established in the region of head, breast and abdomen: suppurative efflux from the nose; erosive stomatitis; shearing of wool; venous congestion in internal organs; necroses, oedema, haemorrhagic and diphtheroid inflammation in rennet, small intestine and colon; yellow-clayey colour of liver; hyperaemia and haemorrhages in kidneys; hyperaemia and oedema in brain envelope and lungs. Histological examination revealed granular or hyaline degeneration in the epithelium of convoluted tubules in cortex in early stages, and thickened basement tubular membranes, as well slight proliferation of connective tissue and mononuclear cell proliferation predominantly in later stages; granular and lipid degeneration, necroses, activation of Kupffer cells, hyperaemia and pericapillar oedema ill liver, abomasitis and duodenitis diphtheroids; degenerative and necrotic changes as well as pericapillar and pericellular oedema in brain and cerebellum.

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Accession: 003207019

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