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Novel feline autoimmune blistering disease resembling bullous pemphigoid in humans: IgG autoantibodies target the NC16A ectodomain of type XVII collagen (BP180/BPAG2)


Novel feline autoimmune blistering disease resembling bullous pemphigoid in humans: IgG autoantibodies target the NC16A ectodomain of type XVII collagen (BP180/BPAG2)



Veterinary Pathology 36(4): 328-335



ISSN/ISBN: 0300-9858

PMID: 10421100

DOI: 10.1354/vp.36-4-328

In 2 adult cats, an acquired dermatosis and stomatitis was diagnosed as bullous pemphigoid (BP) subsequent to the fulfilment of the following criteria: presence of cutaneous vesicles, erosions and ulcers; histological demonstration of subepidermal vesiculation with inflammatory cells, including eosinophils; in vivo deposition of IgG autoantibodies at the epidermal basement membrane zone; and serum IgG autoantibodies targeting a 180-kDa epidermal protein identified as type XVII collagen.

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Accession: 003215135

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Related references

Equine bullous pemphigoid IgG autoantibodies target linear epitopes in the NC16A ectodomain of collagen XVII (BP180, BPAG2). Veterinary Immunology and Immunopathology 73(1): 45-52, 2000

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