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Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex



Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex



Journal of Virology 73(3): 2016-2026



Three viral proteases cleave the 2 polyproteins (the open reading frame 1a and ORF1ab proteins) of equine arteritis virus (EAV) into 12 non-structural proteins, which direct both genome replication and subgenomic mRNA transcription. Immunofluorescence assays showed that most EAV replicase subunits localize to membranes in the perinuclear region of the infected cell.

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Accession: 003220126

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PMID: 9971782


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