+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex

Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex

Journal of Virology 73(3): 2016-2026

Three viral proteases cleave the 2 polyproteins (the open reading frame 1a and ORF1ab proteins) of equine arteritis virus (EAV) into 12 non-structural proteins, which direct both genome replication and subgenomic mRNA transcription. Immunofluorescence assays showed that most EAV replicase subunits localize to membranes in the perinuclear region of the infected cell.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 003220126

Download citation: RISBibTeXText

PMID: 9971782

Related references

Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication. Journal of Virology 73(3): 2027-2037, 1999

ORF1a-encoded replicase subunits are involved in the membrane association of the arterivirus replication complex. Journal of Virology 72(8): 6689-6698, 1998

Ultrastructural characterization of arterivirus replication structures: reshaping the endoplasmic reticulum to accommodate viral RNA synthesis. Journal of Virology 86(5): 2474-2487, 2012

Role of the varicella-zoster virus gene product encoded by open reading frame 35 in viral replication in vitro and in differentiated human skin and T cells in vivo. Journal of Virology 79(8): 4819-4827, 2005

Varicella-zoster virus open reading frame 2 encodes a membrane phosphoprotein that is dispensable for viral replication and for establishment of latency. Journal of Virology 76(7): 3575-3578, 2002

Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication. Journal of Virology 81(19): 10280-10291, 2007

Identification of a protein encoded in the EB-viral open reading frame BMRF2. Archives of Virology 127(1-4): 379-386, 1992

Frog virus 3 open reading frame 97R localizes to the endoplasmic reticulum and induces nuclear invaginations. Journal of Virology 87(16): 9199-9207, 2013

The arterivirus replicase is the only viral protein required for genome replication and subgenomic mRNA transcription. Journal of General Virology 81(Pt 10): 2491-2496, 2000

Murine gammaherpesvirus 68 open reading frame 31 is required for viral replication. Journal of Virology 78(12): 6610-6620, 2004

Interactions between p27 and p88 replicase proteins of Red clover necrotic mosaic virus play an essential role in viral RNA replication and suppression of RNA silencing via the 480-kDa viral replicase complex assembly. Virology 407(2): 213-224, 2010

Nucleotide sequence of hog cholera virus RNA: properties of the polyprotein encoded by the open reading frame spanning the viral genomic RNA. Veterinary Microbiology 23(1-4): 185-191, 1990

Expression of full length hepatitis E virus open reading frame 2 and processing of the major capsid protein in the endoplasmic reticulum of mammalian cells. Hepatology 24(4 Part 2): 412A, 1996

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames. Embo Journal 10(2): 449-457, 1991

Modulation of Borna disease virus phosphoprotein nuclear localization by the viral protein X encoded in the overlapping open reading frame. Journal of Virology 77(14): 8099-8107, 2003