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Precipitation of amphotericin B from i.v. fat emulsion






American Journal of Health-System Pharmacy 54(12): 1449-1449

Precipitation of amphotericin B from i.v. fat emulsion

The possibility of insufficient drug delivery when using amphotericin B prepared in fat emulsion is discussed. When the compatibility of amphotericin B with fat emulsion was examined by measuring interfacial tesion, a problem with precipitation was found with the mixture 15 minutes after preparation.


Accession: 003237834

PMID: 9194992



Related references

Egito, E.Sócrates.T.; Araújo, I.B.; Damasceno, B.P.G.L.; Price, J.C., 2002: Amphotericin B/emulsion admixture interactions: an approach concerning the reduction of amphotericin B toxicity. Mixing FungizoneTM with a fat emulsion used for nutritional purpose (IntralipidTM or LipofundinTM) was reported to decrease Amphotericin B (AmB) toxi city in clinical use. In an effort to understand the reason for this phenomenon, spectral and mor...

Singh, G.Pd.; Saxena, R.K.; Priyadarshy, V., 2010: Amphotericin B--fat emulsion in treatment of visceral leishmaniasis--a cost effective substitute for liposomal amphotericin B. In spite of high dosage and prolonged treatment schedule of sodium antimony gluconate, unresponsiveness and relapse ranging from 25 to 40% has been reported. The cure rate of 90 to 92.9% with amphotericin B-fat emulsion is comparable to that with...

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