EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Preclinical evaluation of a sterically stabilized liposome-encapsulated cisplatin in clinically normal cats


, : Preclinical evaluation of a sterically stabilized liposome-encapsulated cisplatin in clinically normal cats. American Journal of Veterinary Research 59(3): 286-289

Two cats were given multiple i.v. injections of sterically stabilized liposome-encapsulated cisplatin (SSL-CDDP) at a dosage of 70 mg of free CDDP equivalent/msuperscript 2 of body surface area at 3-week intervals. Another 2 cats received single i.v. injections of identical liposome preparations not containing CDDP. Appetite, attitude, thoracic radiographic views, and haematological, serum biochemical and urinalysis findings were evaluated at predetermined intervals.


Accession: 003237931

PMID: 9522946

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Marr, A.K.; Kurzman, I.D.; Vail, D.M., 2004: Preclinical evaluation of a liposome-encapsulated formulation of cisplatin in clinically normal dogs. Objective - To determine the acute and short-term adverse effects of a liposome-encapsulated form of cisplatin at increasing dosages of up to twice the known maximally tolerated dose (MTD) of unencapsulated cisplatin in clinically normal dogs. Ani...

Fox, L.E.; Toshach, K.; Calderwood-Mays, M.; Khokhar, A.R.; Kubilis, P.; Perez-Soler, R.; MacEwen, E.G., 1999: Evaluation of toxicosis of liposome-encapsulated cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) in clinically normal cats. Eight cats were given a single dose of liposome-encapsulated cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) (L-NDDP) at 75, 100, 150 or 200 mg/msuperscript 2, and 2 cats were given liposomal lipid at 1500 mg/msuperscript 2. Si...

Zheng, S.; Zheng, Y.; Beissinger, R.L.; Martin, F.J., 1995: Sterically stabilized liposome-encapsulated hemoglobin. Lasic, D [Editor], Martin, F [Editor] Pharmacology and Toxicology; Basic and clinical aspects: Stealth liposomes 211-218

Zheng, S.; Zheng, Y.; Beissinger, R., 1994: Efficacy, physical properties and pharmacokinetics of sterically-stabilized liposome-encapsulated hemoglobin. We recently reported that hemoglobin (Hb) encapsulated in liposomes (LEH) containing phosphatidyl-inositol (PI) was efficacious in rats. However, liposomes containing PI may temporarily compromise mononuclear phagocytic system (MPS) function. The...

Mandal, T.K.; Darensbourg, J.G., 1996: Preparation and evaluation of sterically stabilized liposome. Pharmaceutical Research (New York) 13(9 SUPPL ): S162

Chen, Y.; Chen, J.; Cheng, Y.; Luo, L.; Zheng, P.; Tong, Y.; Li, Z., 2016: A lyophilized sterically stabilized liposome-containing docetaxel: in vitro and in vivo evaluation. In this study, an improved lyophilized PEGylated liposomal formulation of docetaxel (DOC) has been developed. PEGylated docetaxel liposome (PL-DOC) was prepared by thin-film evaporation method and lyophilization. The effect of various components o...

Parise, A.; Milelli, A.; Tumiatti, V.; Minarini, A.; Neviani, P.; Zuccari, G., 2016: Preparation, characterization and in vitro evaluation of sterically stabilized liposome containing a naphthalenediimide derivative as anticancer agent. The aim of this study was to incorporate a new naphthalenediimide derivative (AN169) with a promising anticancer activity into pegylated liposomes to an extent that allows its in vitro and in vivo testing without use of toxic solvent. AN169-loaded...

Miller, C.R.; Bondurant, B.; McLean, S.D.; McGovern, K.A.; O'Brien, D.F., 1998: Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes. The cellular uptake of liposomes is generally believed to be mediated by adsorption of liposomes onto the cell surface and subsequent endocytosis. This report examines the effect of liposome surface charge on liposomal binding and endocytosis in t...

Yu, K-Fu.; Zhang, W-Qiang.; Luo, L-Min.; Song, P.; Li, D.; Du, R.; Ren, W.; Huang, D.; Lu, W-Liang.; Zhang, X.; Zhang, Q., 2014: The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation. Considering the fact that iRGD (tumor-homing peptide) demonstrates tumor-targeting and tumor-penetrating activity, and that B16-F10 (murine melanoma) cells overexpress both αv integrin receptor and neuropilin-1 (NRP-1), the purpose of this study...

Sant, V.P.; Nagarsenker, M.S.; Rao, S.G.Anand.; Gude, R.P., 2003: Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice. Cytotoxic activity of chemotherapeutic agents can be enhanced by site-specific delivery or by combination with other less toxic agents. In the present study, enhancement in the antimetastatic activity of etoposide (ETP) by encapsulation in sterica...