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Product of the Schistosoma mansoni glutathione peroxidase gene is a selenium containing phospholipid hydroperoxide glutathione peroxidase (PHGPx) sharing molecular weight and substrate specificity with its mammalian counterpart


Product of the Schistosoma mansoni glutathione peroxidase gene is a selenium containing phospholipid hydroperoxide glutathione peroxidase (PHGPx) sharing molecular weight and substrate specificity with its mammalian counterpart



Biomedical and Environmental Sciences: Bes 10(2-3): 209-213



ISSN/ISBN: 0895-3988

PMID: 9315312

A functionally active, monomeric, phospholipid hydroperoxide glutathione peroxidase (PHGPx) was purified and characterized from Schistosoma mansoni. This enzyme contained a catalytically active selenocysteine. The protein was shown to be the product of a cloned gene, previously referred to as a glutathione peroxidase gene. S. mansoni PHGPx was 5-fold more abundant in female than in male worm extract.

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Accession: 003242616

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