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Protection of mice against Trypanosoma cruzi by immunization with paraflagellar rod proteins requires T cell, but not B cell, function






Journal of Immunology 158(11): 5330-5337

Protection of mice against Trypanosoma cruzi by immunization with paraflagellar rod proteins requires T cell, but not B cell, function

The immune response of mice immunized with the paraflagellar rod proteins (PAR) of Trypanosoma cruzi (Peru strain) was investigated. PAR-immunized antibody-deficient ( micro MT) strain mice survived an otherwise lethal T. cruzi challenge, which indicated that a B cell response was not required for PAR-induced immunity.

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Accession: 003245478

PMID: 9164953



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