EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Protective action of dietary protein against monocrotophos toxicity on some biochemical constituents in rats






Indian Journal of Animal Sciences 68(10): 1078-1081

Protective action of dietary protein against monocrotophos toxicity on some biochemical constituents in rats

The effect of a single or repeated oral dose of monocrotophos (2 mg/kg body weight) on certain biochemical constituents was studied in the blood and liver of rats maintained under normal, protein deficient and protein-supplemented dietary conditions. Acute administration at varying intervals induced variable responses. A hyperglycemic and glycogenolytic impact at 12 hr was followed by enhanced glycogenesis accompanied by hypoglycemia at 24 hr in normal rats. In protein malnourished rats, a pronounced hyperglycemia associated with hypolactemia was noticed at 6 hr. Blood lactic acid level continued to be depressed indicating muscular weakness. Chronic exposure of pesticide elevated blood glucose and hepatic lactic acid levels in normal rats. In protein deprived animals, hyperglycemia and hyperlactemia with a concomitant fall in hepatic glycogen and lactic acid were observed. The animals were able to combat the toxic stress of monocrotophos on biochemical constituents when fed on a protein rich diet (10%). A hyperlactemic impact noticed on 7th or 15th day was also alleviated on 30th and 60th day post treatment.

(PDF 0-2 workdays service: $29.90)

Accession: 003245536



Related references

Sharma, N.R.j; Kushwah, A.; Kushwah, H.S., 1997: Protective action of protein against monocrotophos toxicity on brain acetylcholinesterase activity in rats. Indian Veterinary Journal 74(10): 903-905

Ameeta Kushwah; Sharma, N.R.; Kushwah, H.S., 2000: Efficacy of dietary protein in alleviating toxicity of monocrotophos in rats. Monocrotophos administration at intervals induced variable responses in phosphatases, transaminases and aldolase of liver and plasma. Hepato-toxicity was aggravated under protein deficient state. A weak resistance to toxicity was observed in rats...

Kushwah, A.; Sharma, N.R.; Kushwah, H.S., 2001: Efficacy of dietary protein in alleviating toxicity of monocrotophos in rats. Monocrotophos administration at intervals induced variable responses in phosphatases, transaminases and aldolase of liver and plasma. Hepato-toxicity was aggravated under protein deficient state. A weak resistance to toxicity was observed in rats...

Benjamin, N.; Kushwah, A.; Kushwah, H.S., 2001: Efficacy of dietary protein in alleviating monocrotophos toxicity alone or in pesticides mixture in rats. The effect of repeated oral doses of monocrotophos and a mixture of monocrotophos, endosulfan and hexa-chlorocyclohexane (HCH) was studied on brain acetyl-cholinesterase activity in rats fed on varying dietary regimens. Monocrotophos intoxication...

Sharma, N.R.; Ameeta Kushwah; Kushwah, H.S., 2000: Efficacy of dietary protein against monocrotophos toxicity on some carbohydrate metabolic enzymes in rats. A study on carbohydrate metabolic hepatic enzymes was conducted to establish the beneficial effect of dietary protein in alleviating the toxic stress of a single or repeated intubation of monocrotophos (2 mg/kg body weight) in rats maintained on f...

Anonymous, 2009: Fluctuations of certain biochemical constituents and markers enzymes as a consequence of monocrotophos toxicity in the edible freshwater fish, Channa punctatus

Rao, T.B.; Tamhane, D.V.; Sreenivasan, A., 1959: Terramycin and growth. 3. Protective action on certain tissue constituents during protein fasting and regeneration in rats. Earlier work appeared in Antibiotics-A Symposium, Council of Scientific and Industrial Research, New Delhi, 1958. 3. The basal diet, based on Bengal gram flour, was low in methionine and choline. Young rats of average weight 50 g. received that di...

Sandhu H.S.; Malik J.K., 1990: Biochemical alterations induced by subacute toxicity of monocrotophos in bubalus bubalis. Repeated oral administration of monocrotophos in doses of 0.5 and 2.0 mg/kg/day produced significant inactivation of plasma Cholinesterase (24-31%) and serum carboxylesterase (24.5-34.5%) enzymes in buffalo calves. The intensity of enzymes inhibit...

Rajini, P.S.; Krishnakumari, M.K., 1988: Toxicity of pirimiphos-methyl: II. Effect of dietary feeding on blood and urine constituents in albino rats. Growing male rats were fed dietary Pirimiphos-methyl at 0, 500, 1000 and 1500 ppm for 28 days and selected blood and urine constituents were measured at weekly intervals. Dietary intake of Pirimiphos-methyl induced an initial, transient hypoglycem...

Cutts, J.H., 1968: Protective action of diethylstilbestrol on the toxicity of vinblastine in rats. Journal of the National Cancer Institute 41(4): 919-922