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A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids


, : A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. Journal of Biological Chemistry 274(50): 35840-4

Dietary polyunsaturated fatty acids (PUFA) are negative regulators of hepatic lipogenesis that exert their effects primarily at the level of transcription. Sterol regulatory element-binding proteins (SREBPs) are transcription factors responsible for the regulation of cholesterol, fatty acid, and triglyceride synthesis. In particular, SREBP-1 is known to play a crucial role in the regulation of lipogenic gene expression in the liver.

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Accession: 003342466

PMID: 10585468

DOI: 10.1074/jbc.274.50.35840

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Related references

Xu, J.; Nakamura, M.T.; Cho, H.P., 1999: Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression on lipogenic genes by polyunsaturated fats. The Journal of Biological Chemistry 274(33): 577-83

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