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Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes



Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes



Nucleic Acids Research 29(10): 2012-2019



African trypanosomes evade the immune response of their mammalian hosts by sequentially expressing genes for different variant surface glycoproteins (VSGs) from telomere-linked VSG expression sites. In the Trypanosoma brucei clone whose genome is being sequenced (GUTat 10.1), we show that the expressed VSG (VSG 10.1) is duplicated from a silent donor VSG located at another telomere-linked site. We have determined two 130 kb sequences representing the VSG 10.1 donor and expression sites.

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Accession: 003358519

Download citation: RISBibTeXText

PMID: 11353069

DOI: 10.1093/nar/29.10.2012



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