+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Can dietary treatment of non-anemic iron deficiency improve iron status?

Can dietary treatment of non-anemic iron deficiency improve iron status?

Journal of the American College of Nutrition 20(5): 477-484

Objective: To investigate the efficacy of, first, a dietary regimen involving increased consumption of iron-rich foods and enhancers of iron absorption and decreased consumption of inhibitors of iron absorption and, second, a low dose iron chelate iron supplement, for increasing iron stores in young adult New Zealand women with mild iron deficiency (MID). Methods: The study was a 16 week randomized placebo-controlled intervention. Seventy-five women aged 18 to 40 years with MID (serum ferritin <20 microgram/L- and hemoglobin greater than or equal to 120 g/L) were assigned to one of three groups: Placebo, Supplement (50 mg iron/day as amino acid chelate) or Diet. Participants in the Diet Group were given individual dietary counseling to increase the intake and bioavailability of dietary iron. Dietary changes were monitored by a previously validated computer-administered iron food frequency questionnaire. Results: Diet Group members significantly increased their intake of flesh foods, heme iron, vitamin C and foods cooked using cast-iron cookware and significantly decreased their phytate and calcium intakes. Serum ferritin increased in the Supplement and Diet Groups by 59% (p=0.001) and 26% (p=0.068), respectively, in comparison to the Placebo Group. The serum transferrin receptor:serum ferritin ratio decreased by 51% in the Supplement Group (p=0.0001), and there was a non-significant decrease of 22% (p=0.1232) in the Diet Group. Conclusions: This study is the first, to our knowledge, to demonstrate that an intensive dietary program has the potential to improve the iron status of women with iron deficiency.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 003375121

Download citation: RISBibTeXText

PMID: 11601562

DOI: 10.1080/07315724.2001.10719056

Related references

Different degrees of dietary iron repletion on the hepatic iron activities and regulatory proteins in iron deficiency anemic rats. Nutritional Sciences Journal 25(1): 17-28, 2000

Production of iron deficiency anemia and the effect of iron supplementation on the anemic status in rats. Japanese Journal of Nutrition 37(3): 147-154, 1979

Diagnosis of iron deficiency in anemic 1 year old infants the limitations of laboratory tests in predicting response to iron treatment. Pediatric Research 15(4 PART 2): 586, 1981

Report of experience in treatment of childhood iron deficiency anemia with the iron substituting anti-anemic agent Ingoferron. Die Medizinische Welt 46: 2545-2548, 1969

Iron chelated cyclic peptide, ferrichrysin, for oral treatment of iron deficiency: solution properties and efficacy in anemic rats. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 77(1): 13-21, 2007

Oral sucrosomial iron versus intravenous iron in anemic cancer patients without iron deficiency receiving darbepoetin alfa: a pilot study. Supportive Care in Cancer 25(9): 2779-2786, 2017

Effect of soybean hull iron on growth, iron bioavailability, and behavioral function in anemic rats induced by iron deficiency during gestation or lactation. Nutrition Research 19(12): 1749-1761, 1999

Effects of wheat flour fortified with different iron fortificants on iron status and anemia prevalence in iron deficient anemic students in Northern China. Asia Pacific Journal of Clinical Nutrition 16(1): 116-121, 2007

Increased intestinal iron absorption in rats with normal hepatic iron stores. Kinetic aspects of the adaptative response to parenteral iron repletion in dietary iron deficiency. Biochimica et Biophysica Acta 1033(3): 277-281, 1990

Dietary iron and fat affect nonheme iron absorption, iron status, and enterocyte aconitase activity and iron concentration in rats. Nutrition Research 16(6): 977-989, 1996

Effect of protein deficiency and dietary iron level on performance and hematic iron status of weanling pigs. Journal of Animal Science 51(Suppl. 1): 80, 1980

Dietary phosphate supplementation delays the onset of iron deficiency anemia and affects iron status in rats. Nutrition Research 35(11): 1016-1024, 2016

Iron status in Danish women, 1984-1994: a cohort comparison of changes in iron stores and the prevalence of iron deficiency and iron overload. European Journal of Haematology 71(1): 51-61, 2003

Iron status in Danish men 1984-94: a cohort comparison of changes in iron stores and the prevalence of iron deficiency and iron overload. European Journal of Haematology 68(6): 332-340, 2002

Effect of iron-deficiency anemia on certain hematological values, dietary iron absorption and nutritional status of growing rats. Iraqi Journal of Veterinary Sciences 16(2): 201-214, 2002