EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Cellular immune response cytokine expression during the initial stage of bovine leukemia virus (BLV) infection determines the disease progression to persistent lymphocytosis


Cellular immune response cytokine expression during the initial stage of bovine leukemia virus (BLV) infection determines the disease progression to persistent lymphocytosis



Comparative Immunology Microbiology and Infectious Diseases 23(3): 197-208



ISSN/ISBN: 0147-9571

PMID: 10855665

DOI: 10.1016/s0147-9571(99)00074-0

We have established experimental models of bovine leukemia virus (BLV) infection followed by progression to persistent lymphocytosis (PL) positive (BLV+PL+) or PL negative (BLV+PL-) stages of infection. Two out of six BLV infected animals developed PL+ 4 weeks after BLV infection. One other animal became PL+ late in the course of infection and three infected animals stayed PL-. These animals (PL-) exhibited transient lymphocytosis 3-4 weeks after infection and sustained PL- lymphocyte counts up to 24 weeks after infection. Competitive RT-PCR analysis of IFN-gamma mRNA expression revealed that peripheral blood mononuclear cells (PBMC) of animals with PL+ status developed by 4 weeks after infection had augmented IFN-gamma mRNA expression 3-4 weeks after BLV infection. However PBMC of animals that sustained a long-termed PL- lymphocyte count had elevated IFN-gamma mRNA expression 1-24 weeks after infection. Competitive RT-PCR analysis of IL-2 mRNA expression showed an increase in the levels of IL-2 mRNA in PL animals. Interleukin-10 (IL-10) mRNAs expression were elevated both in PL+ and PL- animals from 3 and 12 weeks after infection respectively. We suggest that early and extended expression of cellular response cytokines may delay the progression to PL+ in enzootic bovine leukemia.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003377195

Download citation: RISBibTeXText

Related references

Cytokine mRNA expression in B cells from bovine leukemia virus-infected cattle with persistent lymphocytosis. Cytokine 28(1): 25-28, 2004

Progression to persistent lymphocytosis and tumor development in bovine leukemia virus (BLV)-infected cattle correlates with impaired proliferation of CD4+ T cells in response to gag- and env-encoded BLV proteins. Journal of Virology 70(11): 7584-7593, 1996

Polymorphism of bola drb3 exon 2 determines resistance and susceptibility to persistent lymphocytosis caused by bovine leukemia virus. FASEB Journal 6(5): A1711, 1992

Cellular basis of persistent lymphocytosis in cattle infected with bovine leukemia virus. Infection and Immunity 16(3): 891-897, 1977

Analysis of Syk expression in bovine lymphoma and persistent lymphocytosis induced by bovine leukemia virus. Journal of Veterinary Medical Science 73(1): 41-45, 2011

Studies on the relationship between infection with bovine C-type virus, leukemia, and persistent lymphocytosis in cattle. Cancer Research 34(4): 893-900, 1974

Studies on the development of persistent lymphocytosis and infection with the bovine C-type leukemia virus (BLV) in cattle. Veterinary Microbiology 1(2/3): 287-300, 1976

Development and serial passage of persistent lymphocytosis associated with bovine leukemia virus infection in cattle. Nihon Juigaku Zasshi. Japanese Journal of Veterinary Science 51(1): 60-69, 1989

Progression to persistent lymphocytosis and tumor development in bovine leukemia virus infected cattle impairs proliferation of CD4+ T-cells to gag and env encoded proteins of BLV. FASEB Journal 10(6): A1318, 1996

Detection of bovine leukemia virus infection by 2 commercial immunodiffusion tests and its relationship with persistent lymphocytosis. Ciencia e Investigacion Agraria 11(3): 223-228, 1984

Characteristics of lymphocytes appearing in persistent lymphocytosis induced experimentally in cattle by bovine leukemia virus infection. Nihon Juigaku Zasshi. Japanese Journal of Veterinary Science 51(1): 70-78, 1989

Reduced IL-2 and IL-4 mRNA expression in CD4+ T cells from bovine leukemia virus-infected cows with persistent lymphocytosis. Virology 304(1): 1-9, 2002

Study of the relationships between infection by blv bovine leukemia virus persistent lymphocytosis and infections by other infectious agents in a cattle herd. Annales de Medecine Veterinaire 133(6): 515-524, 1989

Stimulation of humoral and cellular immune response in experimental infection with bovine leukemia virus. Latvijas Psr Zinatnu Akademijas Vestis 11: 75-83, 1986

Interleukin-12 p40 mRNA expression in bovine leukemia virus-infected animals: increase in alymphocytosis but decrease in persistent lymphocytosis. Journal of Virology 72(8): 6917-6921, 1998