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Characterization of two structural forms of otonecine-type pyrrolizidine alkaloids from Ligularia hodgsonii by NMR spectroscopy



Characterization of two structural forms of otonecine-type pyrrolizidine alkaloids from Ligularia hodgsonii by NMR spectroscopy



Journal of Natural Products 63(6): 857-860



Clivorine and ligularine, 2 hepatotoxic otonecine-type pyrrolizidine alkaloids isolated from L. hodgsonii, an antitussive traditional Chinese medicine, were investigated in CDCl<sub>3</sub> and D<sub>2</sub>O by various NMR techniques to delineate why this type of alkaloid displays uncharacteristic solubility properties by dissolving in both nonpolar organic and aqueous solutions.

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Accession: 003380993

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PMID: 10869221

DOI: 10.1021/np9906119


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