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Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans


Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans



Molecular and Cellular Biology 20(23): 8696-8708



ISSN/ISBN: 0270-7306

PMID: 11073971

DOI: 10.1128/mcb.20.23.8696-8708.2000

Both mitogen-activated protein kinases and cyclin-dependent kinases play a role in hyphal development in Candida albicans. Using an oligonucleotide probe-based screen, we have isolated a new member of the Cdc2 kinase subfamily, designated Crk1 (Cdc2-related kinase). The protein sequence of Crk1 is most similar to those of Saccharomyces cerevisiae Sgv1 and human PKl1/Cdk9. In S. cerevisiae, CRK1 suppresses some, but not all, of the defects associated with an sgv1 mutant.

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Accession: 003395369

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