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Detection of antibodies to Candida albicans germ tubes in heroin addicts with systemic candidiasis



Detection of antibodies to Candida albicans germ tubes in heroin addicts with systemic candidiasis



Clinical Microbiology and Infection 7(4): 224-226



87 serum samples were drawn from 67 intravenous heroin addict patients in Spain, from January 1993 to November 1995, to evaluate the presence of C. albicans germ tube (CAGT) antibodies. Group I consisted of 33 intravenous brown heroin addicts with systemic candidosis: all but 2 had human immunodeficiency virus (HIV) infection (31 males and 2 females, aged 18-47 years). Group II consisted of 34 patients (intravenous heroin addicts with HIV) who had an infectious disease other than candidosis (26 males and 8 females, aged 12-69 years). Group III consisted of 60 healthy blood donors (38 males and 22 females, aged 20-50 years). Antibody detection was performed in adsorbed sera by indirect immunofluorescence assay. In group I, CAGT antibodies were detected in 45 of the 47 sera (95.74%) from 32 of 33 patients (96.9%). Titres ranged from 1:20 to 1:280, mostly between 1:20 and 1:40. The one patient negative for CAGT antibodies was positive for Candida krusei. No CAGT antibodies were detected in groups II and III.

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Accession: 003400917

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PMID: 11422247

DOI: 10.1046/j.1198-743x.2001.00229.x


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