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Chapter 3,404

Development of an effective polyvalent vaccine against both Marek's and Newcastle diseases based on recombinant Marek's disease virus type 1 in commercial chickens with maternal antibodies

Sonoda, K.; Sakaguchi, M.; Okamura, H.; Yokogawa, K.; Tokunaga, E.; Tokiyoshi, S.; Kawaguchi, Y.; Hirai, K.

Journal of Virology 74(7): 3217-3226

2000


ISSN/ISBN: 0022-538X
PMID: 10708438
DOI: 10.1128/jvi.74.7.3217-3226.2000
Accession: 003403862

An earlier report showed that recombinant Marek's disease virus type 1 (rMDV1) expressing the fusion (F) protein of Newcastle disease virus (NDV-F) under the control of the simian virus 40 late promoter (rMDV1-US10L(F)) protected specific pathogen-free chickens from NDV challenge, but not commercial chickens with maternal antibodies against NDV and MDV1.

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