EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Disposition of oxytetracycline in pigs after i.m. administration of two long-acting formulations


, : Disposition of oxytetracycline in pigs after i.m. administration of two long-acting formulations. Journal of Veterinary Pharmacology and Therapeutics 24(4): 247-250

Two commercially available long-acting oxytetracycline (OTC) formulations were administered by the intramuscular (i.m.) route to six healthy pigs at the recommended dose of 30 mg/kg. After 2 h the mean maximum concentration (Cmax) reached values of 8.1 +/- 2.2 and 15.4 +/- 11.1 microgram/mL, respectively. These concentrations remained higher than 0.5 microgram/mL for more than 5 days after drug administration. The area under the concentration time curve (AUC(0-9 days)) of each formulation was 255 +/- 76.5 and 399.2 +/- 123 microgram(.)h/mL, respectively, and the mean residence time (MRT) was around 3 days for both formulations. No significant differences were observed between the pharmacokinetic parameters of the two formulations, showing the bioequivalence of the two formulations studied according to the criteria established by the Food and Drug Administration (FDA) and the Committee for Veterinary Medicinal Products (CVMP).

Accession: 003408552

PMID: 11555179

DOI: 10.1046/j.1365-2885.2001.00342.x

Download PDF Full Text: Disposition of oxytetracycline in pigs after i.m. administration of two long-acting formulations


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Mestorino, N.; Marchetti, Mía.Laura.; Lucas, M.Florencia.; Modamio, P.; Zeinsteger, P.; Fernández Lastra, C.; Segarra, I.; Mariño, E.Luis., 2016: Bioequivalence Study of Two Long-Acting Formulations of Oxytetracycline Following Intramuscular Administration in Bovines. The aim of this study was to evaluate the bioequivalence of two commercial long-acting formulations based on oxytetracycline (OTC) hydrochloride between the reference formulation (Terramycin LA, Pfizer) and a test formulation (Cyamicin LA, Fort Do...

Gberindyer, A.F.; Okpeh, E.R.; Semaka, A.A., 2016: Pharmacokinetics of Short- and Long-acting Formulations of Oxytetracycline After Intramuscular Administration in Chickens. Both short- and long-acting formulations of oxytetracycline are commonly used in veterinary medicine to treat animals infected with gram-negative and gram-positive bacteria, rickettsiae, mycoplasma, and chlamydiae. To compare pharmacokinetics of s...

Guyonnet, J.; Pacaud, M.; Richard, M.; Kaltsatos, V., 2000: Bioequivalence study of two long-acting formulations of oxytetracycline following intramuscular administration in the sheep. The aim of this study was to demonstrate the bioequivalence of two formulations based on oxytetracycline between a test formulation (TENALINEReg. LA Bovins - Porcins) and the reference oxytetracycline according to a framework required for the regi...

Petzer I M.; Van Staden J.J.; Giesecke E.W.H., 1984: Tissue reaction and residues in slaughter cattle after administration of long acting oxytetracycline formulations. Samples from 40 slaughter cattle were investigated over 10 wk for determining macroscopic tissue reaction following i.m. administration of Liquamycin/LA (Pfizers) into the thigh and Terramycin/LA (Pfizers) G 333 into the neck, respectively. Antibi...

Petzer, I.M.; van Staden, J.J.; Giesecke, W.H., 1984: Tissue reactions and residues in slaughter cattle after administration of long-acting oxytetracycline formulations. Samples from 40 slaughter cattle were investigated over 10 weeks for determining macroscopic tissue reaction following intramuscular administration of Liquamycin/LA (Pfizers) into the thigh and Terramycin/LA (Pfizers) G 333 into the neck respectiv...

Domb, Abraham J., 1995: Long acting injectable oxytetracycline-liposphere formulations. Oxytetracycline (OTC) was encapsulated in a liposphere delivery system composed of OTC, solid triglyceride, phospholipid, buffer solution and preservatives. The formulation is an injectable microdispersion containing 8-20 wt% OTC with an average p...

Archimbault, P.; Navetat, H.; Vidal, R.; Douin, M.J.; Mignot, A., 1994: Plasma bioavailability of 2 long-acting oxytetracycline of formulations in the pig. Two commercially available long-acting oxytetracycline (OTC-LA) formulations were administered by intramuscular injection in 2 groups of 10 clinically healthy pigs at the recommended dose level of 20 mg/kg. Plasma concentrations were analysed by h...

Archimbault, P.; Navetat, H.; Vidal, R.; Douin, M.J.; Mignot, A., 1994: Plasma bioavailability of 2 long-acting oxytetracycline formulations in the pig. Two commercially available long-acting oxytetracycline (OTC-LA) formulations were administered by intramuscular injection in 2 groups of 10 clinically healthy pigs at the recommended dose level of 20 mg/kg. Plasma concentrations were analysed by h...

Anonymous, 2005: Disposition kinetics of oxytetracycline-long acting in buffalo calves

Turel, I.; Dagoglu, G.; Yilmaz, O.; Yarsan, E.; Irak, K., 2005: Pharmacokinetics of long acting and conventional formulations of oxytetracycline in goats. The pharmacokinetics of oxytetracycline (OTC) were investigated in coloured Mohair goats, after the intravenous (i.v. at 10 and 20 mg/kg body weight) and intramuscular (i.m. at 10 and 20 mg/kg body weight) injection of a conventional and a long-ac...