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Distinct humoral and cellular immune response to an immunogenic caprine arthritis encephalitis virus p25-Gag peptide in homozygous goats of different MHC-haplotypes


Archiv fur Tierzucht 42(Special issue): 133-137
Distinct humoral and cellular immune response to an immunogenic caprine arthritis encephalitis virus p25-Gag peptide in homozygous goats of different MHC-haplotypes
An association of the caprine class I MHC antigen Be1 marked haplotype and onset of caprine arthritis (CAE) has previously been demonstrated. In this experiment, Be1-D5 haplotype carriers as well as goats expressing an non disease-associated haplotype Be10-D2 were backcrossed in order to explore potential differences in their respective immune responses. Six homozygous animals per group were immunized with a synthetic peptide containing a B- and T- cell epitope.

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Accession: 003408785



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